NetPro™ Application Areas

Drug Discovery:

Netpro™ is rich in both protein-protein, protein-small molecule data and covers majority of human CYPs. This data is valuable in terms of studying drug-drug and drug-protein interactions. ....

• Assists in target identification, lead optimization and drug repositioning.
• Provides data on drug metabolism, pharmacokinetics, metabolomics and pharmacogenomics.
• Extensive coverage on SAR, QSAR, drug synergism, drug antagonism and prodrug activation data.

Insights into disease pathology:

Disease data in NetPro™ describes the role of a protein/ compund as a potential therapeutic target or a therapeutic agent. This data helps in narrowing down on Drug candidates with therapeutic relevance. ....

• Provides data on gene over/under expressed, mutated/modified in a disease and therapeutically potential targets/agents.
• Quantitative or qualitative information of molecular interactions in a disease state.

Insights into Enzyme action:

NetPro™ also provides a wide range of inhibitor details for proteases involved in various pathological conditions. ....

• A wide class of enzymes and exhaustive collection of substrates /inhibitors with kinetic values.

Better design of experiments:

• Failed agonist/antagonist interactions with SAR data and contrasting interactions due to variation in experimental context provide better insight into molecular mechanisms and also help in avoiding unnecessary experiments saving both cost and time.