| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 9010 | IL1A | Protein | Homo sapiens-e | Increases degradation | indirect | NFKBIA | Protein | Homo sapiens | | | Although NF-kappaB is involved in regulating
the IL-1alpha-induced expression of MCP-1 and IL-8, the
degradation of IkappaB-alpha stimulated by IL-1alpha was not
inhibited by alprazolam. | | | |
Interaction id | 9010 | |
MOLECULE A | |
Id | 3552 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 4792 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases degradation (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
Experimental location and method | - species::Human
- cell::T98G cells
| |
References | |
PubMed Id | 12218154 | |
Author | Oda T, Ueda A, Sh, imizu N, Handa H, Kasahara T | |
Title | Suppression of monocyte chemoattractant protein 1, but not
IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and
c-Rel/p50 binding to the monocyte chemoattractant protein 1
promoter region. |
|
|
| | |
| 83907 | Fas | Protein | Mus musculus | Increases phosphorylation | indirect | Nfkbia | Protein | Mus musculus | | | In fibroblast strains derived from these
embryos, the TNF receptors, Fas/Apo1, and DR3 were able to
activate the Jun N-terminal kinase and to trigger IkappaB
alpha phosphorylation and degradation. | | | |
Interaction id | 83907 | |
MOLECULE A | |
Id | 14102 |
Type | Protein |
Species | Mus musculus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 18035 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases phosphorylation (
indirect ) | |
Pathway | Apoptosis:Caspase Activation | |
Experimental location and method | - species::Mouse- Caspase 8 null embryos
- cell::Fibroblasts
| |
References | |
PubMed Id | 9729047 | |
Author | Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N,
Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC,
Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T,
Holtmann H, Lonai P, Wallach D | |
Title | Targeted disruption of the mouse Caspase 8 gene ablates cell
death induction by the TNF receptors, Fas/Apo1, and DR3 and is
lethal prenatally. |
|
|
| | |
| 83911 | Fas | Protein | Mus musculus | Increases degradation | indirect | Nfkbia | Protein | Mus musculus | | | In fibroblast strains derived from these
embryos, the TNF receptors, Fas/Apo1, and DR3 were able to
activate the Jun N-terminal kinase and to trigger IkappaB
alpha phosphorylation and degradation. | | | |
Interaction id | 83911 | |
MOLECULE A | |
Id | 14102 |
Type | Protein |
Species | Mus musculus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 18035 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases degradation (
indirect ) | |
Pathway | Apoptosis:Caspase ActivationCytokine And Chemokine Mediated Signaling
Pathway:TNF Signaling Pathway | |
Experimental location and method | - species::Mouse- Caspase 8 null embryos
- cell::Fibroblasts
| |
References | |
PubMed Id | 9729047 | |
Author | Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N,
Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC,
Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T,
Holtmann H, Lonai P, Wallach D | |
Title | Targeted disruption of the mouse Caspase 8 gene ablates cell
death induction by the TNF receptors, Fas/Apo1, and DR3 and is
lethal prenatally. |
|
|
| | |
| 86029 | IL1A | Protein | Homo sapiens-e | Increases phosphorylation | indirect | NFKBIA | Protein | Homo sapiens-e | | | In addition, sorbitol and H(2)O(2) blocked
TNF-induced but not interleukin-1-induced IkappaBalpha
phosphorylation, whereas arsenite inhibited IkappaBalpha
phosphorylation induced by TNF and interleukin-1. | | | |
Interaction id | 86029 | |
MOLECULE A | |
Id | 3552 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 4792 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | | | Kinetics | - | |
|
General Information |
Interaction term | Increases phosphorylation (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
References | |
PubMed Id | 10428782 | |
Author | Alpert D, Schwenger P, Han J, Vilcek J | |
Title | Cell stress and MKK6b-mediated p38 MAP kinase activation
inhibit tumor necrosis factor-induced IkappaB phosphorylation
and NF-kappaB activation. |
|
|
| | |
| 91525 | NFKBIA | Protein | Homo sapiens-e | Inhibits expression | indirect | CCL2 | Protein | Homo sapiens | | | In contrast, expression of the CC chemokines
MIP-1alpha, MCP-1 and RANTES inducedby TNFalpha or LPS was
significantly inhibited by the overexpression of IkappaBalpha. | | | |
Interaction id | 91525 | |
MOLECULE A | |
Id | 4792 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 6347 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits expression (
indirect ) | |
Pathway | Protein Kinase Cascade:I-Kappab Kinase/Nf-Kappab Cascade | |
Experimental location and method | - species::Human
- cell::Monocyte-derived macrophages
| |
References | |
PubMed Id | 12115625 | |
Author | Ciesielski CJ, Andreakos E, Foxwell BM, Feldmann M | |
Title | TNFalpha-induced macrophage chemokine secretion is more
dependent on NF-kappaB expression than
lipopolysaccharides-induced macrophage chemokine secretion. |
|
|
| | |
| 191595 | IL1B | Protein | Homo sapiens-e | Increases degradation | indirect | Nfkbia | Protein | Rattus norvegicus | | | Transient nuclear factor kappaB (NF-kappaB)
activation stimulated by interleukin-1beta may be partly
dependent on proteasome activity, but not phosphorylation
and ubiquitination of the IkappaBalpha molecule, in C6
glioma cells. Regulation of NF-kappaB linked to chemokine
production. / Nascent IkappaBalpha began to degrade 5 min
after treatment with IL-1beta and disappeared completely
after 15 min. | | | |
Interaction id | 191595 | |
MOLECULE A | |
Id | 3553 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 25493 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | | Mol B | | Conc | Time | Others | Comments | | after5min
| | Detectable / apparent
|
|
| Mol B | | Conc | Time | Others | Comments | | after15min
| | Complete degradation
|
|
| Mol B | | Conc | Time | Others | Comments | | after45 to 60min
| | Returned to basal level
|
|
| |
|
General Information |
Interaction term | Increases degradation (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
Experimental location and method | - species::Rat
- cell::C6 cells
| |
References | |
PubMed Id | 10336492 | |
Author | Uehara T, Matsuno J, Kaneko M, Nishiya T, Fujimuro M,
Yokosawa H, Nomura Y | |
Title | Transient nuclear factor kappaB (NF-kappaB) activation
stimulated by interleukin-1beta may be partly dependent on
proteasome activity, but not phosphorylation and ubiquitination
of the IkappaBalpha molecule, in C6 glioma cells. Regulation of
NF-kappaB linked to chemokine production. |
|
|
| |
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d: for diseases
Regulator