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Modules
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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
11889PTGS2ProteinHomo sapiens-eIncreases expressionindirectBCL2ProteinHomo sapiens
Forced COX-2 expression significantly attenuated TRAIL-induced apoptosis and was associated with transcriptional repression of DR-5 and up-regulation of Bcl-2.
Disease
88744CEBPBProteinHomo sapiens-eIncreases activitydirectBCL2DNAHomo sapiens-e
Expression of C/EBPalpha increased bcl-2 expression, and two regions of the bcl-2 P2 promoter that mediated this effect were identified. C/EBPbeta was also able to increase bcl-2 promoter activity through these sites. / Decreased expression of C/EBP factors due to targeting of their transcripts by siRNA molecules resulted in downregulation of Bcl-2 protein.
Structure
Disease

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