| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 9010 | IL1A | Protein | Homo sapiens-e | Increases degradation | indirect | NFKBIA | Protein | Homo sapiens | | | Although NF-kappaB is involved in regulating
the IL-1alpha-induced expression of MCP-1 and IL-8, the
degradation of IkappaB-alpha stimulated by IL-1alpha was not
inhibited by alprazolam. | | | |
Interaction id | 9010 | |
MOLECULE A | |
Id | 3552 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 4792 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases degradation (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
Experimental location and method | - species::Human
- cell::T98G cells
| |
References | |
PubMed Id | 12218154 | |
Author | Oda T, Ueda A, Sh, imizu N, Handa H, Kasahara T | |
Title | Suppression of monocyte chemoattractant protein 1, but not
IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and
c-Rel/p50 binding to the monocyte chemoattractant protein 1
promoter region. |
|
|
| | |
| 86029 | IL1A | Protein | Homo sapiens-e | Increases phosphorylation | indirect | NFKBIA | Protein | Homo sapiens-e | | | In addition, sorbitol and H(2)O(2) blocked
TNF-induced but not interleukin-1-induced IkappaBalpha
phosphorylation, whereas arsenite inhibited IkappaBalpha
phosphorylation induced by TNF and interleukin-1. | | | |
Interaction id | 86029 | |
MOLECULE A | |
Id | 3552 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 4792 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | | | Kinetics | - | |
|
General Information |
Interaction term | Increases phosphorylation (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
References | |
PubMed Id | 10428782 | |
Author | Alpert D, Schwenger P, Han J, Vilcek J | |
Title | Cell stress and MKK6b-mediated p38 MAP kinase activation
inhibit tumor necrosis factor-induced IkappaB phosphorylation
and NF-kappaB activation. |
|
|
| |
|
d: for diseases
Regulator