| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 85680 | CHRM2 | Protein | Homo sapiens-e | Increases activity | indirect | PLA2G4A | Protein | Homo sapiens-e | | | The pathway initiated by m2 receptors
involved sequential activation of Gbetagamma(i3),
phosphatidylinositol (PI)3-kinase, Cdc42, and Rac1,
p21-activated kinase (PAK1), p38 mitogen-activated protein
(MAP) kinase, and cPLA(2), and phosphorylation of cPLA(2) at Ser(505). | | | |
Interaction id | 85680 | |
MOLECULE A | |
Id | 1129 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5321 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Positive | | Description | PI3K, CDC42, RAC1, PAK1, MAPK14 |
| |
Regulation | Negative | | Description | Methoctramine, LY294002, SB 203580 |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | G-Protein Coupled Receptor Protein Signaling
Pathway:Acetylcholine Receptor Signaling, Muscarinic Pathway | |
Experimental location and method | - organ / tissue::Smooth muscle
| |
References | |
PubMed Id | 12576304 | |
Author | Zhou H, Das S, Murthy KS | |
Title | Erk1/2- and p38 MAP kinase-dependent phosphorylation and
activation of cPLA2 by m3 and m2 receptors. |
|
|
| | |
| 85681 | CHRM2 | Protein | Homo sapiens-e | Increases phosphorylation | indirect | PLA2G4A | Protein | Homo sapiens-e | | | The pathway initiated by m2 receptors
involved sequential activation of Gbetagamma(i3),
phosphatidylinositol (PI)3-kinase, Cdc42, and Rac1,
p21-activated kinase (PAK1), p38 mitogen-activated protein
(MAP) kinase, and cPLA(2), and phosphorylation of cPLA(2) at Ser(505). | | | |
Interaction id | 85681 | |
MOLECULE A | |
Id | 1129 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5321 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Positive | | Description | PI3K, CDC42, RAC1, PAK1, MAPK14 |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Increases phosphorylation (
indirect ) | |
Pathway | G-Protein Coupled Receptor Protein Signaling
Pathway:Acetylcholine Receptor Signaling, Muscarinic Pathway | |
Experimental location and method | - organ / tissue::Smooth muscle
| |
Comments | |
Domain_motif_site_residue | | (PF01735)[RES:Ser505](5321) |
| |
References | |
PubMed Id | 12576304 | |
Author | Zhou H, Das S, Murthy KS | |
Title | Erk1/2- and p38 MAP kinase-dependent phosphorylation and
activation of cPLA2 by m3 and m2 receptors. |
|
|
| |
|
d: for diseases
Regulator