| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 85115 | Amifostine | Small molecule | Small molecule | Decreases expression | indirect | TNF | Protein | Homo sapiens | | | Moreover, we tested the ability of such
antioxidant agents to reduce the serum levels of
proinflammatory cytokines IL-6 and TNFalpha. / The selected
antioxidant agents were: alpha lipoic acid or
carboxycysteine-lysine salt, amifostine, reduced
glutathione, vitamin A plus vitamin E plus Vitamin C. /
Moreover, the antioxidant treatment was able to reduce serum
levels of IL-6 and TNFalpha. | | | |
Interaction id | 85115 | |
MOLECULE A | |
Id | 20537-88-6 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 7124 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Decreases expression (
indirect ) | |
Pathway | Response to Stress:Response to Oxidative Stress | |
Experimental location and method |
| |
References | |
PubMed Id | 12653210 | |
Author | Mantovani G, Maccio A, Madeddu C, Mura L, Gramignano G,
Lusso MR, Murgia V, Camboni P, Ferreli L, Mocci M, Massa E | |
Title | The impact of different antioxidant agents alone or in
combination on reactive oxygen species, antioxidant enzymes and
cytokines in a series of advanced cancer patients at different
sites: correlation with disease progression. |
|
|
| |
|
d: for diseases
