| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 83907 | Fas | Protein | Mus musculus | Increases phosphorylation | indirect | Nfkbia | Protein | Mus musculus | | | In fibroblast strains derived from these
embryos, the TNF receptors, Fas/Apo1, and DR3 were able to
activate the Jun N-terminal kinase and to trigger IkappaB
alpha phosphorylation and degradation. | | | |
Interaction id | 83907 | |
MOLECULE A | |
Id | 14102 |
Type | Protein |
Species | Mus musculus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 18035 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases phosphorylation (
indirect ) | |
Pathway | Apoptosis:Caspase Activation | |
Experimental location and method | - species::Mouse- Caspase 8 null embryos
- cell::Fibroblasts
| |
References | |
PubMed Id | 9729047 | |
Author | Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N,
Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC,
Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T,
Holtmann H, Lonai P, Wallach D | |
Title | Targeted disruption of the mouse Caspase 8 gene ablates cell
death induction by the TNF receptors, Fas/Apo1, and DR3 and is
lethal prenatally. |
|
|
| | |
| 83911 | Fas | Protein | Mus musculus | Increases degradation | indirect | Nfkbia | Protein | Mus musculus | | | In fibroblast strains derived from these
embryos, the TNF receptors, Fas/Apo1, and DR3 were able to
activate the Jun N-terminal kinase and to trigger IkappaB
alpha phosphorylation and degradation. | | | |
Interaction id | 83911 | |
MOLECULE A | |
Id | 14102 |
Type | Protein |
Species | Mus musculus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 18035 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases degradation (
indirect ) | |
Pathway | Apoptosis:Caspase ActivationCytokine And Chemokine Mediated Signaling
Pathway:TNF Signaling Pathway | |
Experimental location and method | - species::Mouse- Caspase 8 null embryos
- cell::Fibroblasts
| |
References | |
PubMed Id | 9729047 | |
Author | Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N,
Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC,
Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T,
Holtmann H, Lonai P, Wallach D | |
Title | Targeted disruption of the mouse Caspase 8 gene ablates cell
death induction by the TNF receptors, Fas/Apo1, and DR3 and is
lethal prenatally. |
|
|
| |
|
d: for diseases
