| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 80170 | Ketamine | Small molecule | Small molecule | Inhibits activity | indirect | Tnf | Protein | Rattus norvegicus | | | All animals were pretreated intraperitoneally
with CAR (150 mg/kg) 16 hr before LPS stimulation. The
control rats were injected LPS with 0.5 mg/kg intravenously
(i.v.). The ketamine-treated rats were injected with 100
mg/kg of ketamine intramuscularly 30 min before LPS (0.5
mg/kg) i.v. injection, followed by an i.v. infusion at 0, 5,
or 10 mg/kg/hr. Serum TNF-alpha, ABGs, blood glucose, and
hematological studies were determined at 0, 2, and 6 hr
after the LPS challenge. Serum hepatocellular enzyme levels
were measured at 6 hr after the injection. / By contrast,
ketamine treatment significantly attenuated the decrease in
MAP and LPS-induced TNF-alpha activity. | | | |
Interaction id | 80170 | |
MOLECULE A | |
Id | 6740-88-1 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 24835 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | | Mol A | | Conc | Time | Others | Comments | 100mg/kg
| 0hrs
2hrs
6hrs
| | Intramuscular
30 min before LPS (0.5 mg/kg) i.v.
injection, followed by an i.v. infusion at
0, 5, or 10 mg/kg/hr.
|
|
| |
|
General Information |
Interaction term | Inhibits activity (
indirect ) | |
Pathway | Immune Response:Inflammatory Response | |
Experimental location and method | - species::Rat
- condition::Carrageenan-sensitized
endotoxin shock rat model
| |
References | |
PubMed Id | 7600640 | |
Author | Koga K, Ogata M, Takenaka I, Matsumoto T, Shigematsu A | |
Title | Ketamine suppresses tumor necrosis factor-alpha activity and
mortality in carrageenan-sensitized endotoxin shock model. |
|
|
| |
|
d: for diseases
