| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 74966 | Pioglitazone | Small molecule | Small molecule | Increases activity | direct | PPARG | Protein | Homo sapiens | | | Troglitazone and pioglitazone, which are
ligands/activators for PPARgamma, also induced PPARalpha
gene and protein expression and increased CuZn-SOD gene
expression and protein levels in addition to increasing
PPARgamma gene and protein expression in endothelial cells. | | | |
Interaction id | 74966 | |
MOLECULE A | |
Id | 111025-46-8 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5468 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Ligand-dependent nuclear receptor
activity:Peroxisome proliferator associated receptor activity | |
Experimental location and method | - species::Human
- cell::Umbilical vein endothelial cells,
human aorta endothelial cells
| |
References | |
PubMed Id | 11172467 | |
Author | Inoue I, Goto S, Matsunaga T, Nakajima T, Awata T, Hokari
S, Komoda T, Katayama S | |
Title | The ligands/activators for peroxisome proliferator-activated
receptor alpha (PPARalpha) and PPARgamma increase
Cu2+,Zn2+-superoxide dismutase and decrease p22phox message
expressions in primary endothelial cells. |
|
|
| |
|
d: for diseases
