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Patients were randomly assigned into two
groups, receiving PTXF in a dose of 5 mg/kg per hour for 6 h
or placebo (saline), on 3 successive days. / There was a
statistically significant decrease in plasma TNF level in
the PTXF group when the values before the first and after
the last PTXF infusion were compared [mean: 671.5 pg/ml; SD:
438; med: 729.6 vs mean: 41.0 pg/ml; SD: 64.1; med: 11.5; P
< 0.000004]. / PTXF inhibits production of TNF and may
have therapeutic value in the treatment of premature infants
with sepsis complicated by shock.