| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 74265 | CDK5R1 | Protein | Homo sapiens-e | Increases activity | direct | CDK5 | Protein | Homo sapiens | | | Cdk5 is activated by the association with its
regulatory partner p35 or its truncated form, p25, which is
elevated in AD brains. /In this study, we investigated
APP(Thr668) phosphorylation and APP processing mediated by
p35/Cdk5 and p25/Cdk5 in the human neuroblastoma cell line
SH-SY5Y. / These results confirm the involvement of Cdk5 in
APP processing, and suggest that p35- and p25-mediated Cdk5
activities lead to discrete APP phosphorylation. | | | |
Interaction id | 74265 | |
MOLECULE A | |
Id | 8851 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 1020 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | | |
Interaction result | |
Other Resultant | | Leads to APP phosphorylation |
| |
Disease Details | | disease: :Alzheimer Disease |
| |
Experimental location and method | - species::Human
- cell::SHSY5Y cells
| |
Comments | |
Property | | Overexpressed p35 and truncated isoform p25 of CDK5R1 |
| |
References | |
PubMed Id | 12860412 | |
Author | Liu F, Su Y, Li B, Zhou Y, Ryder J, Gonzalez-DeWhitt P, May
PC, Ni B | |
Title | Regulation of amyloid precursor protein (APP) phosphorylation
and processing by p35/Cdk5 and p25/Cdk5. |
|
|
| | |
| 81836 | Calpain | Multi subunit | Homo sapiens-e | Cleave | direct | Cdk5r1 | Protein | Rattus norvegicus | | | To test this hypothesis, we induced
calpain-mediated p35 cleavage in rat hippocampal neuronal
cultures and studied the relationship between p25
production, cdk5 activity, and tau phosphorylation. In
glutamate-treated cells p35 was cleaved to p25 and this was
associated with elevated cdk5 activity. / The calpain
inhibitor MDL28170 prevented the cleavage of p35 but had no
effect on tau phosphorylation, suggesting that
calpain-mediated processes, i.e., the cleavage of p35 to p25
and cdk5 activation, do not contribute to tau
phosphorylation in these conditions. | | | |
Interaction id | 81836 | |
MOLECULE A | |
Id | EZHsM00015 |
Type | Multi subunit |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 116671 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | | | Kinetics | - | |
|
General Information |
Interaction term | Cleave (
direct ) | |
Pathway | Endopeptidase activity:Calpain activity | |
Interaction result | |
Other Resultant | | Leads to the activation of Cdk5 |
| |
Experimental location and method | - species::Rat
- condition::Glutamate treated cells
- cell::Hippocampal neuronal cells
| |
Comments | |
Property | | Produces a p25 fragment |
| |
References | |
PubMed Id | 12419309 | |
Author | Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttila T | |
Title | Cleavage of the cyclin-dependent kinase 5 activator p35 to
p25 does not induce tau hyperphosphorylation. |
|
|
| | |
| 152545 | APP | Protein | Homo sapiens-e | Increases cleavage | indirect | CDK5R1 | Protein | Homo sapiens-e | | | Stabilization of the cyclin-dependent kinase
5 activator, p35, by paclitaxel decreases beta-amyloid
toxicity in cortical neurons. / Taxol did not inhibit cdk5
directly but significantly blocked Abeta-induced calpain
activation and decreased formation of the cdk5 activator,
p25, from p35. | | | |
Interaction id | 152545 | |
MOLECULE A | |
Id | 351 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 8851 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | | | Kinetics | - | |
|
General Information |
Interaction term | Increases cleavage (
indirect ) | |
Pathway | NeurogenesisEndopeptidase activity:Calpain activity | |
Interaction result | |
Other Resultant | | Leads to formation of activated form of CDK5R1(p25) |
| |
Disease Details | | disease: :Alzheimer Disease |
| |
Experimental location and method |
| |
References | |
PubMed Id | 12558997 | |
Author | Li G, Faibushevich A, Turunen BJ, Yoon SO, Georg G,
Michaelis ML, Dobrowsky RT | |
Title | Stabilization of the cyclin-dependent kinase 5 activator,
p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons. |
|
|
| |
|
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