| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 72055 | ADAM9 | Protein | Homo sapiens-e | Cleave | direct | APP | Protein | Homo sapiens-e | | | Further, when MDC9 was co-expressed in COS
cells with amyloid precursor protein (APP695) and treated
with phorbol ester, APP695 was digested exclusively at the
alpha-secretory site in MDC9-expressing cells. | | | |
Interaction id | 72055 | |
MOLECULE A | |
Id | 8754 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 351 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Cleave (
direct ) | |
Pathway | Extracellular matrix:Matrix metalloproteinase
associated interactions | |
Experimental location and method |
| |
Comments | |
Domain_motif_site_residue | | alpha-secretory site (APP) |
| |
References | |
PubMed Id | 10510302 | |
Author | Koike H, Tomioka S, Sorimachi H, Saido TC, Maruyama K,
Okuyama A, Fujisawa-Sehara A, Ohno S, Suzuki K, Ishiura S | |
Title | Membrane-anchored metalloprotease MDC9 has an alpha-secretase
activity responsible for processing the amyloid precursor protein. |
|
|
| |
|
d: for diseases
Structure