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Progesterone (25 mg/kg of body weight) or
vehicle was administered subcutaneously at the end of
resuscitation. / Animals treated with progesterone showed
significantly reduced levels of the TNF-alpha, IL-6, and
transaminases as well as reduced myeloperoxidase activity in
the liver. / In vitro treatment of Kupffer cells with
progesterone decreased TNF-alpha production but did not
affect the production of IL-6.