| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 68437 | PSEN2 | Protein | Homo sapiens | Increases expression | indirect | APP | Protein | Homo sapiens | | | In the transfected cells, PS1 and PS2
mutations caused a highly significant increase in A beta 42
secretion in all mutant clones. / Likewise, mutant but not
wildtype PS1 transgenic mice showed significant
overproduction of A beta 42 in the brain, and this effect
was detectable as early as 2-4 months of age. | | | |
Interaction id | 68437 | |
MOLECULE A | |
Id | 5664 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | disease: :Alzheimer Diseasemutation: :Mutatedsignificance: :Mutated | |
MOLECULE B | |
Id | 351 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | | |
Disease Details | | disease: :Alzheimer Disease |
| |
Experimental location and method | - species::PSEN2 transgenic Mouse
- organ / tissue::Brain
| |
Comments | |
Property | | Mutant PSEN2;A beta 42 |
| |
References | |
PubMed Id | 8986743 | |
Author | Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque
G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D,
Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I,
Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ | |
Title | Mutant presenilins of Alzheimer's disease increase
production of 42-residue amyloid beta-protein in both
transfected cells and transgenic mice. |
|
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| |
|
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