| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 68364 | Alendronic acid | Small molecule | Small molecule | Inhibits expression | indirect | TNF | Protein | Homo sapiens | | | Alendronate exhibited dose-dependent
inhibition of the production of interleukin-1 beta (IL-1
beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha
(TNF-alpha) by activated monocytes. The inhibitory effect of
10(-6) M alendronate on PBMC proliferation was reversed by
10 U/ml recombinant rIL-1 beta, whereas other cytokines such
as IL-6, TNF-alpha, and granulocyte-macrophage
colony-stimulating factor (GM-CSF) had no effect. | | | |
Interaction id | 68364 | |
MOLECULE A | |
Id | 66376-36-1 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 7124 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits expression (
indirect ) | |
Pathway | Antigen Receptor-Mediated Signaling Pathway | |
Experimental location and method | - species::Human
- cell::Peripheral blood mononuclear cells
| |
References | |
PubMed Id | 8592949 | |
Author | Sansoni P, Passeri G, Fagnoni F, Mohagheghpour N, Snelli G,
Brianti V, Engleman EG | |
Title | Inhibition of antigen-presenting cell function by alendronate
in vitro. |
|
|
| |
|
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Regulator