| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 2160 | BDNF | Protein | Homo sapiens-e | Increases expression | indirect | SYP | Protein | Homo sapiens-e | | | BDNF also increased the levels of the vesicle
proteins synaptophysin, synaptobrevin, and synaptotagmin,
without affecting the presynaptic membrane proteins syntaxin
and SNAP-25, or the vesicle-binding protein synapsin-I. | | | |
Interaction id | 2160 | |
MOLECULE A | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 6855 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Transmembrane Receptor Protein Tyrosine Kinase
Signaling Pathway:Brain-Derived Neurotrophic Factor
Receptor Signaling Pathway | |
References | |
PubMed Id | 11483592 | |
Author | Tartaglia N, Du J, Tyler WJ, Neale E, Pozzo-Miller L, Lu B | |
Title | Protein synthesis-dependent and -independent regulation of
hippocampal synapses by brain-derived neurotrophic factor. |
|
|
| | |
| 27629 | IL1B | Protein | Homo sapiens-e | Decreases expression | indirect | SYP | Protein | Homo sapiens-e | | | When such activated microglia were placed in
coculture with primary neocortical neurons, a significant
increase in the phosphorylation of neuronal tau was
accompanied by a decline in synaptophysin levels. Similar
effects were evoked by treatment of neurons with recombinant IL-1beta. | | | |
Interaction id | 27629 | |
MOLECULE A | |
Id | 3553 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 6855 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Decreases expression (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
Disease Details | | disease: :Alzheimer Disease |
| |
Experimental location and method | - cell::Neocortical neurons
| |
References | |
PubMed Id | 12629164 | |
Author | Li Y, Liu L, Barger SW, Griffin WS | |
Title | Interleukin-1 mediates pathological effects of microglia on
tau phosphorylation and on synaptophysin synthesis in cortical
neurons through a p38-MAPK pathway. |
|
|
| | |
| 118325 | IL1A | Protein | Homo sapiens-e | Decreases expression | indirect | SYP | Protein | Homo sapiens-e | | | As a direct test of the requirement for IL-1
in tau phosphorylation and synaptophysin expression, IL-1
actions in neuron-microglia cocultures were manipulated.
Activation of microglia with secreted beta-amyloid precursor
protein or lipopolysaccharide elevated their expression of
IL-1alpha, IL-1beta, and tumor necrosis factor alpha
(TNFalpha) mRNA. When such activated microglia were placed
in coculture with primary neocortical neurons, a significant
increase in the phosphorylation of neuronal tau was
accompanied by a decline in synaptophysin levels. Similar
effects were evoked by treatment of neurons with recombinant IL-1beta. | | | |
Interaction id | 118325 | |
MOLECULE A | |
Id | 3552 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 6855 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Decreases expression (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
Experimental location and method | - condition::Neuron-microglia cocultures
- cell::Microglia cells
| |
References | |
PubMed Id | 12629164 | |
Author | Li Y, Liu L, Barger SW, Griffin WS | |
Title | Interleukin-1 mediates pathological effects of microglia on
tau phosphorylation and on synaptophysin synthesis in cortical
neurons through a p38-MAPK pathway. |
|
|
| |
|
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