| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 66116 | Hydrogen peroxide | Small molecule | Small molecule | Increases activity | indirect | CASP3 | Protein | Homo sapiens-e | | | The membrane-permeable cGMP analog
dibutyryl-cGMP attenuated the H(2)O(2)-induced decrease in
cell viability, DNA ladder formation, nuclear condensation,
reduction of the mitochondrial membrane potential,
cytochrome c release from mitochondria, and caspase-3
activation in cultured astrocytes. / The PTP inhibitors
cyclosporin A and bongkrekic acid prevented the
H(2)O(2)-induced decrease in cell viability and caspase-3 activation. | | | |
Interaction id | 66116 | |
MOLECULE A | |
Id | 7722-84-1 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 836 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Negative | | Description | Cyclosporin A, Bongkrekic acid,
Dibutyryl 3',5'-cyclic GMP |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Apoptosis:Caspase ActivationResponse to Stress:Response to Oxidative Stress | |
Experimental location and method |
| |
References | |
PubMed Id | 11677240 | |
Author | Takuma K, Phuagphong P, Lee E, Mori K, Baba A, Matsuda T | |
Title | Anti-apoptotic effect of cGMP in cultured astrocytes:
inhibition by cGMP-dependent protein kinase of mitochondrial
permeable transition pore. |
|
|
| | |
| 87378 | Hydrogen peroxide | Small molecule | Small molecule | Increases activity | indirect | MAP3K5 | Protein | Homo sapiens-e | | | Treatment of cells with N-acetyl-L-cysteine
also inhibited serum withdrawal-, TNF-alpha- and hydrogen
peroxide-induced activation of ASK1 as well as apoptosis. | | | |
Interaction id | 87378 | |
MOLECULE A | |
Id | 7722-84-1 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 4217 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Negative | | Description | Acetylcysteine |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | | |
References | |
PubMed Id | 9564042 | |
Author | Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada
Y, Kawabata M, Miyazono K, Ichijo H | |
Title | Mammalian thioredoxin is a direct inhibitor of apoptosis
signal-regulating kinase (ASK) 1. |
|
|
| | |
| 164872 | APP | Protein | Homo sapiens | Increases level | indirect | Hydrogen peroxide | Small molecule | Small molecule | | | In Alzheimer's disease (AD), amyloid
beta-peptide (A beta) fibrils accumulate in plaques which
are associated with degenerating neurons. / We now report
that bFGF can protect cultured hippocampal neurons against A
beta25-35 toxicity by a mechanism that involves suppression
of reactive oxygen species (ROS) accumulation and
maintenance of Na+/K+-ATPase activity. A beta25-35 induced
lipid peroxidation, accumulation of H2O2, mitochondrial ROS
accumulation, and a decrease in mitochondrial transmembrane
potential; each of these effects of A beta25-35 was
abrogated in cultures pre-treated with bFGF. | | | |
Interaction id | 164872 | |
MOLECULE A | |
Id | 351 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | Hydrogen peroxide |
Type | Small molecule |
Species | Small molecule | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | | | Kinetics | - | |
|
General Information |
Interaction term | Increases level (
indirect ) | |
Pathway | NeurogenesisResponse to Stress:Response to Oxidative Stress | |
Disease Details | | disease: :Alzheimer Disease |
| |
Experimental location and method | - cell::Neurons
- sub cellular::Mitochondria
- organ / tissue::Hippocampus
| |
Comments | |
Property | | 25-35 peptide of APP |
| |
References | |
PubMed Id | 9187334 | |
Author | Mark RJ, Keller JN, Kruman I, Mattson MP | |
Title | Basic FGF attenuates amyloid beta-peptide-induced oxidative
stress, mitochondrial dysfunction, and impairment of
Na+/K+-ATPase activity in hippocampal neurons. |
|
|
| |
|
d: for diseases
Regulator