| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 64102 | Sodium salicylate | Small molecule | Small molecule | Inhibits expression | indirect | TNF | RNA | Homo sapiens | | | In addition, sodium salicylate and additional
NSAIDs used at concentrations that activate HSF1 also
inhibited the expression of other monocytic genes
(TNF-alpha, IL-1beta, IL-6, IL-8, IL-10, ICAM-1) activated
by exposure to a pro-inflammatory stimulus
(lipopolysaccharide, LPS). | | | |
Interaction id | 64102 | |
MOLECULE A | |
Id | 54-21-7 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 7124 |
Type | RNA |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits expression (
indirect ) | |
Pathway | Response to Stimulus:Response to Drug | |
Experimental location and method | - species::Human
- cell::THP-1 cells
| |
References | |
PubMed Id | 10328874 | |
Author | Housby JN, Cahill CM, Chu B, Prevelige R, Bickford K,
Stevenson MA, Calderwood SK | |
Title | Non-steroidal anti-inflammatory drugs inhibit the expression
of cytokines and induce HSP70 in human monocytes. |
|
|
| |
|
d: for diseases
