| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 53249 | NFKB1 | Protein | Homo sapiens-e | Bind | direct | RELB | Protein | Homo sapiens | |
| We demonstrate that human RelB (I-Rel) forms
with p50 and p52 (p50B) kappa B-binding heterodimeric
complexes which potently transactivate kappa B-dependent
constructs in transfection studies. | |
| |
Interaction id | 53249 | |
MOLECULE A | |
Id | 4790 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5971 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Bind (
direct ) | |
Pathway | Protein Kinase Cascade:I-Kappab Kinase/Nf-Kappab Cascade | |
References | |
PubMed Id | 8183565 | |
Author | Bours V, Azarenko V, Dejardin E, Siebenlist U | |
Title | Human RelB (I-Rel) functions as a kappa B site-dependent
transactivating member of the family of Rel-related proteins. |
|
|
|
|
|
| 121720 | NF-kappa-B | Multi subunit | Homo sapiens | Increases activity | direct | NFKB1 | DNA | Homo sapiens | |
| Ku antigen, RBP-Jk and p50 were found to bind
to the DNA region containing the kB element in the p50
promoter. / mRNA expression and de novo synthesis of p50
were inhibited in cells transfected with the mutated gene
expression constructs for IkBa, Ku80 and RBP-Jk. A reporter
assay demonstrated that p50 transcription was positively
mediated by NF-kB, Ku antigen and RBP-Jk, and that the
binding elements for these proteins are required for optimal
p50 expression. | |
| |
Interaction id | 121720 | |
MOLECULE A | |
Id | TRHsM00001 |
Type | Multi subunit |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 4790 |
Type | DNA |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Protein Kinase Cascade:I-Kappab Kinase/Nf-Kappab Cascade | |
Experimental location and method | - Experimental method::Reporter gene assay
- species::Human
- cell::AGS cells
| |
References | |
PubMed Id | 14570916 | |
Author | Lim JW, Kim H, Kim KH | |
Title | Ku antigen-RBP-Jk complex binds to NF-kB p50 promoter and
acts as a positive regulator of p50 expression in human gastric
cancer cells. |
|
|
|
|
|
| 232093 | LYL1 | Protein | Homo sapiens-e | Bind | direct | NFKB1 | Protein | Homo sapiens-e | |
| A yeast two-hybrid system was used to
identify proteins that specifically interact with LYL1 and
might mediate its activities. We found that p105, the
precursor of NF-kappaB1 p50, was the major LYL1-interacting
protein in this system. The association between LYL1 and
p105 was confirmed both in vitro and in vivo in mammalian
cells. Biochemical studies indicated that the interaction
was mediated by the bHLH motif of LYL1 and the ankyrin-like
motifs of p105. Ectopic expression of LYL1 in a human T cell
line caused a significant decrease in NF-kappaB-dependent
transcription, associated with a reduced level of NF-kappaB1 proteins. | |
| |
Interaction id | 232093 | |
MOLECULE A | |
Id | 4066 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 4790 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Bind (
direct ) | |
Experimental location and method | - Experimental method::Yeast two hybrid assay
- cell::Mammalian cells
| |
Comments | |
Property | | p105 form of NFKB1 |
Domain_motif_site_residue | | (PF00010)(4066) |
General | | LYL1 binds to NFKB1 and makes it unavilable for
NF-kappaB activity |
| |
References | |
PubMed Id | 10023675 | |
Author | Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J,
Mathieu-Mahul D | |
Title | Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. |
|
|
|
|
|
| 431823 | TNF | Protein | Homo sapiens-e | Increases expression | indirect | NFKB1 | RNA | Homo sapiens-e | |
| We investigated the regulatory effect of
highly N-acetylated COS (NACOS) on tumor necrosis
factor-alpha (TNF-alpha)-induced endothelial cell (EC)
E-selectin expression, which is crucial for leukocyte
recruitment. / Pre-treating ECs with NACOS inhibited the
TNF-alpha-induced p65 and p50 mRNA expressions. | |
| |
Interaction id | 431823 | |
MOLECULE A | |
Id | 7124 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 4790 |
Type | RNA |
Species | Homo sapiens-e | |
Attribute | Variant::NFKB-p50 |
Structure Details | -- |
Disease Details | -- | | Kinetics | | Mol A | | Conc | Time | Others | Comments | | 4hrs
| | |
|
| |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Experimental location and method | - Location context::Interaction specific
- cell / cell line::Endothelial Cells
- primary::N
| |
Comments | |
General | | Highly N-acetylated chitooligosaccharides inhibited
the TNF-alpha-induced NFKB1 expression |
| |
References | |
PubMed Id | 17126899 | |
Author | Lin CW, Chen LJ, Lee PL, Lee CI, Lin JC, Chiu JJ | |
Title | The inhibition of TNF-alpha-induced E-selectin expression in
endothelial cells via the JNK/NF-kappaB pathways by highly
N-acetylated chitooligosaccharides. |
|
|
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