| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 21555 | BDNF | Protein | Homo sapiens-e | Increases activity | indirect | AKT | Family | Homo sapiens-e | |
| BDNF and NMDA increased Akt phosphorylation
within 5 minutes but maximal activation by NMDA was observed
at 3 hours. | |
| |
Interaction id | 21555 | |
MOLECULE A | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | EZHsF00022 |
Type | Family |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Negative | | Description | LY294002, K252a |
|
| | Kinetics | | Mol B | | Conc | Time | Others | Comments | | <=5min
| | |
|
| |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Transmembrane receptor activity:Glial cell
line-derived neurotrophic factor receptor activity | |
Experimental location and method | - cell::Cerebellar granule cell neurons
| |
References | |
PubMed Id | 12373512 | |
Author | Zhu D, Lipsky RH, Marini AM | |
Title | Co-activation of the phosphatidylinositol-3-kinase/Akt
signaling pathway by N-methyl-D-aspartate and TrkB receptors in
cerebellar granule cell neurons. |
|
|
|
|
|
| 439996 | Phosphoinositide-3-kinase | Protein | Rattus norvegicus | Increases activity | indirect | AKT | Protein | Rattus norvegicus | |
| Neuroprotective effects of the synthetic
cannabinoid HU-210 in primary cortical neurons are mediated
by phosphatidylinositol 3-kinase/AKT signaling. / The
neurotoxin S-AMPA induced significant death of rat primary
cortical neurons, which was inhibited by the CB agonist
HU-210. / HU-210 triggered activation of AKT, but not
activation of the ERK1/2, JNK or p38 signaling pathways. The
phosphatidylinositol 3-kinase (PI 3-K) inhibitors LY294002
and wortmannin prevented phosphorylation of AKT in response
to HU-210, and reversed the neuroprotective effect of HU-210
on S-AMPA-induced excitotoxicity. | |
| |
Interaction id | 439996 | |
MOLECULE A | |
Id | EZRnM00003 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | EZRnF00022 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Id | 112830-95-2 : HU-210 |
Type | Small molecule |
Species | Small molecule | |
Structure Details | |
Disease Details | | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Interaction result | |
Other Resultant | | Inhibits S-AMPA-induced excitotoxicity |
| |
Experimental location and method | - Location context::Interaction specific
- species::Rat
- cell / cell line::Cortical neurons
- primary::Y
| |
References | |
PubMed Id | 15607953 | |
Author | Molina-Holgado F, Pinteaux E, Heenan L, Moore JD, Rothwell
NJ, Gibson RM | |
Title | Neuroprotective effects of the synthetic cannabinoid HU-210
in primary cortical neurons are mediated by phosphatidylinositol
3-kinase/AKT signaling. |
|
|
|
|
|
| 440503 | AKT | Protein | Homo sapiens | Decreases activity | indirect | GSK3B | Protein | Homo sapiens | |
| In the present studies, we examined the
relationship between Akt and T212/S214 in primary cultures
of human neurons and astrocytes, and evaluated the
contribution of two other kinases. / In comparison, okadaic
acid treatment severely depleted the content of GSK3beta and
downregulated the remaining GSK3beta activity by
Akt-dependent inhibition, consistent with minimal changes in phospho-T212. | |
| |
Interaction id | 440503 | |
MOLECULE A | |
Id | EZHsF00022 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 2932 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Decreases activity (
indirect ) | |
Experimental location and method | - Location context::Interaction specific
- species::Human
- cell / cell line::Neurons
- primary::Y
- Location context::Interaction specific
- species::Human
- cell / cell line::Astrocytes
- primary::Y
| |
References | |
PubMed Id | 15283964 | |
Author | Kyoung Pyo H, Lovati E, Pasinetti GM, Ksiezak-Reding H | |
Title | Phosphorylation of tau at THR212 and SER214 in human neuronal
and glial cultures: the role of AKT. |
|
|
|
|
d: for diseases
Regulator