| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 77850 | Activator protein 1 | Multi subunit | Homo sapiens-e | Increases activity | direct | FAS | DNA | Homo sapiens | | | Our present study identified an upstream
enhancer element (between nucleotide positions -862 and
-682) containing a GA-binding protein (GABP) site and a low
affinity activating protein-1 (AP-1)-binding site. T cell
activation increased the DNA binding of GABP and AP-1 to
this enhancer site. / Taken together, these results suggest
that the transcription factors GABP and AP-1 play a critical
role in the induction of Fas gene expression in T cell
antigen receptor.CD3-stimulated Jurkat cells. | | | |
Interaction id | 77850 | |
MOLECULE A | |
Id | TRHsM00014 |
Type | Multi subunit |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 355 |
Type | DNA |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Regulation of transcription | |
Experimental location and method | - Experimental method::Electrophoretic
Mobility Shift Assay
- species::Human
- condition::T cell antigen receptor and
CD3 complex stimulated jurkat cells
- cell::Jurkat cells
| |
Comments | |
Domain_motif_site_residue | | [US:-862 to -682](355) |
| |
References | |
PubMed Id | 10575005 | |
Author | Li XR, Chong AS, Wu J, Roebuck KA, Kumar A, Parrillo JE,
Rapp UR, Kimberly RP, Williams JW, Xu X | |
Title | Transcriptional regulation of Fas gene expression by
GA-binding protein and AP-1 in T cell antigen receptor.CD3
complex-stimulated T cells. |
|
|
| | |
| 422289 | IL1B | Protein | Homo sapiens-e | Increases activity | indirect | Activator protein 1 | Protein | Homo sapiens | | | The present study was undertaken to
investigate the mechanism of expression of inducible nitric
oxide synthase (iNOS) in human primary astrocytes. / All
three cytokines alone induced the activation of AP-1 while
IL-1beta and TNF-alpha but not IFN-gamma induced the
activation of NF-kappaB. / Consistently, JNK-I, a specific
inhibitor of JNK, inhibited IL-1beta-mediated activation of
AP-1 and expression of iNOS. | | | |
Interaction id | 422289 | |
MOLECULE A | |
Id | 3553 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | TRHsM00014 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Experimental location and method | - Location context::Interaction specific
- species::Human
- cell / cell line::Astrocytes
- primary::Y
| |
References | |
PubMed Id | 15683721 | |
Author | Jana M, Anderson JA, Saha RN, Liu X, Pahan K | |
Title | Regulation of inducible nitric oxide synthase in
proinflammatory cytokine-stimulated human primary astrocytes. |
|
|
| |
|
d: for diseases
Structure