| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 5289 | MAP2K4 | Protein | Homo sapiens | Increases activity | direct | MAPK8 | Protein | Homo sapiens | | | Although SEK and MKK7 acted downstream of
TAK1, only a kinase-defective SEK mutant blocked
TGF-beta-induced activation of JNK1, indicating that the
TGF-beta signal is relayed solely through SEK, but not MKK7,
in vivo. | | | |
Interaction id | 5289 | |
MOLECULE A | |
Id | 6416 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5599 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Protein kinase activity:Protein serine/threonine
kinase activity (non receptor)Transmembrane Receptor Protein Serine/Threonine
Kinase Signaling Pathway:Transforming Growth Factor
Beta Receptor Signaling Pathway | |
Experimental location and method | - species::Human
- cell::293T cells
| |
References | |
PubMed Id | 10224067 | |
Author | Zhou G, Lee SC, Yao Z, Tan TH | |
Title | Hematopoietic progenitor kinase 1 is a component of
transforming growth factor beta-induced c-Jun N-terminal kinase
signaling cascade. |
|
|
| | |
| 232128 | MAPK8 | Protein | Homo sapiens | Phosphorylate | direct | HIPK1 | Protein | Homo sapiens | | | Role of the ASK1-SEK1-JNK1-HIPK1 signal in
Daxx trafficking and ASK1 oligomerization. / Overexpression
of JNK binding domain inhibited glucose deprivation-induced
JNK1 activation, relocalization of Daxx from the nucleus to
the cytoplasm, and apoptosis signal-regulating kinase 1
(ASK1) oligomerization in human prostate adenocarcinoma
DU-145 cells. / Studies from in vivo labeling and immune
complex kinase assay demonstrated that phosphorylation of
Daxx occurred during glucose deprivation, and its
phosphorylation was mediated through the
ASK1-SEK1-JNK1-HIPK1 signal transduction pathway. / Taken
together, these results show that glucose deprivation
activates the ASK1-SEK1-JNK1-HIPK1 pathway, and the
activated HIPK1 is probably involved in the relocalization
of Daxx from the nucleus to the cytoplasm. | | | |
Interaction id | 232128 | |
MOLECULE A | |
Id | 5599 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 204851 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Phosphorylate (
direct ) | |
Experimental location and method | - species::Human
- condition::Glucose deprivation
- cell::DU145 cells
| |
References | |
PubMed Id | 12968034 | |
Author | Song JJ, Lee YJ | |
Title | Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking
and ASK1 oligomerization. |
|
|
| | |
| 422166 | MAPK8 | Protein | Homo sapiens | Increases activity | indirect | CASP3 | Protein | Homo sapiens | | | Here, we report that Cd treatment of SH-SY5Y
cells caused apoptosis through sequential phosphorylation of
the apoptosis signal regulating kinase 1, MAPK kinase 4,
c-Jun N-terminal kinase (JNK), and c-Jun as determined by
overexpression of dominant negative (DN) constructs of these
genes or using a specific JNK inhibitor SP600125. / In
addition, caspase inhibitors, zDEVD and zVAD, reduced
apoptosis but not JNK and c-Jun phosphorylation induced by
Cd, while overexpression of DN JNK1 inhibited caspase-3 activity. | | | |
Interaction id | 422166 | |
MOLECULE A | |
Id | 5599 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 836 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Experimental location and method | - Location context::Interaction specific
- species::Human
- cell / cell line::SH-SY5Y
- primary::N
- Experimental method::Dominant negative analysis
- Method details::Mol A
| |
References | |
PubMed Id | 15670787 | |
Author | Kim SD, Moon CK, Eun SY, Ryu PD, Jo SA | |
Title | Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a
signaling cascade involved in cadmium-induced neuronal cell apoptosis. |
|
|
| |
|
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