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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
421747GenisteinSmall moleculeSmall moleculeInhibits expressionindirectTNFRNAHomo sapiens-e
Tyrosine kinase inhibitors attenuate Japanese encephalitis virus-induced neurotoxicity. / PTK inhibitors, genistein, herbimycin A, and PP2, attenuated JEV-induced neurotoxicity but failed to affect JEV replication. Infection of neuron/glia cultures with JEV produced elevated levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). PTK inhibitors suppressed JEV-induced TNF-alpha and IL-1beta production at the transcriptional level. Our results suggest that PTKs, especially Src-related PTK, play roles in the production of TNF-alpha and IL-1beta during JEV infection and in the induction of neuronal death in neuron/glia cultures.
Regulator

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