| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 34098 | TNF | Protein | Homo sapiens-e | Increases expression | indirect | PLA2G4A | RNA | Homo sapiens | | | Phospholipase A(2) (PLA(2)) is a growing
family of enzymes that may play a major role in inflammation
/ The cells were stimulated with TNF-alpha or IFN-gamma for
different lengths of time (1, 4, 18, and 48 h), and the mRNA
levels of the different PLA(2) types were determined by
reverse transcriptase-PCR (RT-PCR) and normalized to those
of the housekeeping gene, GAPDH. In both cell lines,
TNF-alpha increased the expression of PLA(2) IVA and IVC,
and IFN-gamma increased the expression of PLA(2) IIA and IID. | | | |
Interaction id | 34098 | |
MOLECULE A | |
Id | 7124 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5321 |
Type | RNA |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | | Mol A | | Conc | Time | Others | Comments | | 1hrs
4hrs
18hrs
48hrs
| | |
|
| |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:TNF Signaling Pathway | |
Disease Details | | |
Experimental location and method | - Experimental method::Polymerase Chain Reaction
- species::Human
- cell::RPMI 2650, BEAS-2B cells
| |
References | |
PubMed Id | 12396716 | |
Author | Lindbom J, Ljungman AG, Lindahl M, Tagesson C | |
Title | Increased gene expression of novel cytosolic and secretory
phospholipase A(2) types in human airway epithelial cells
induced by tumor necrosis factor-alpha and IFN-gamma. |
|
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| |
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