| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 26712 | IL1A | Protein | Homo sapiens-e | Increases activity | indirect | p38 MAPK | Family | Homo sapiens-e | | | In cell culture, 5Z-7-oxozeaenol blocked
interleukin-1-induced activation of TAK1, JNK/p38 MAPK,
IkappaB kinases, and NF-kappaB, resulting in inhibition of
cyclooxgenase-2 production. | | | |
Interaction id | 26712 | |
MOLECULE A | |
Id | 3552 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | EZHsF00051 |
Type | Family |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Negative | | Description | 5Z-7-oxozeaenol |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
References | |
PubMed Id | 12624112 | |
Author | Ninomiya-Tsuji J, Kajino T, Ono K, Ohtomo T, Matsumoto M,
Shiina M, Mihara M, Tsuchiya M, Matsumoto K | |
Title | A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents
inflammation by inhibiting the catalytic activity of TAK1 MAPK
kinase kinase. |
|
|
| |
|
d: for diseases
Regulator