| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 25717 | HSPB1 | Protein | Homo sapiens-e | Decreases translocation | direct | DAXX | Protein | Homo sapiens-e | |
| HSP27 also prevents the translocation of Daxx
from the nucleus to the cytoplasm | |
| |
Interaction id | 25717 | |
MOLECULE A | |
Id | 3315 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 1616 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Decreases translocation (
direct ) | |
Pathway | Response to Stress :Response to Heat | |
Experimental location and method | - sub cellular::Nucleus to the cytoplasm
| |
References | |
PubMed Id | 11193028 | |
Author | Charette SJ, Landry J | |
Title | The interaction of HSP27 with Daxx identifies a potential
regulatory role of HSP27 in Fas-induced apoptosis. |
|
|
|
|
|
| 26212 | FAS | Protein | Homo sapiens-e | Increases translocation | indirect | DAXX | Protein | Homo sapiens-e | |
| However, HSP27 blocked Fas-induced
translocation of Daxx from the nucleus to the cytoplasm and
Fas-induced Daxx- and Ask1-dependent apoptosis. | |
| |
Interaction id | 26212 | |
MOLECULE A | |
Id | 355 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 1616 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Negative | | Description | Heat shock 27kDa protein |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Increases translocation (
indirect ) | |
Pathway | Apoptosis:Induction of Apoptosis Via Death Domain Receptors | |
Experimental location and method | - sub cellular::Nucleus to cytoplasm
| |
References | |
PubMed Id | 11003656 | |
Author | Charette SJ, Lavoie JN, Lambert H, Landry J | |
Title | Inhibition of Daxx-mediated apoptosis by heat shock protein 27. |
|
|
|
|
|
| 26213 | DAXX | Protein | Homo sapiens-e | Bind | direct | FAS | Protein | Homo sapiens-e | |
| Here we show that phosphorylated dimers of
HSP27 interact with Daxx, a mediator of Fas-induced
apoptosis, preventing the interaction of Daxx with both Ask1
and Fas and blocking Daxx-mediated apoptosis. | |
| |
Interaction id | 26213 | |
MOLECULE A | |
Id | 1616 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 355 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Negative | | Description | Heat shock 27kDa protein |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Bind (
direct ) | |
Pathway | Apoptosis:Induction of Apoptosis Via Death Domain Receptors | |
References | |
PubMed Id | 11003656 | |
Author | Charette SJ, Lavoie JN, Lambert H, Landry J | |
Title | Inhibition of Daxx-mediated apoptosis by heat shock protein 27. |
|
|
|
|
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Regulator