| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 23766 | HSPB1 | Protein | Homo sapiens-e | Inhibits activity | direct | CASP3 | Protein | Homo sapiens-e | | | Here we demonstrate that heat-shock protein
27 (Hsp27) inhibits cytochrome c (cyt c)-dependent
activation of cas-3. / By contrast, our results show that
Hsp27 associates with cas-3, but not Apaf-1 or cas-9, and
inhibits activation of cas-3 by cas-9-mediated proteolysis. | | | |
Interaction id | 23766 | |
MOLECULE A | |
Id | 3315 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 836 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits activity (
direct ) | |
Pathway | Apoptosis:Apoptotic Mitochondrial ChangesApoptosis:Caspase Activation | |
References | |
PubMed Id | 10803458 | |
Author | Pandey P, Farber R, Nakazawa A, Kumar S, Bharti A, Nalin C,
Weichselbaum R, Kufe D, Kharbanda S | |
Title | Hsp27 functions as a negative regulator of cytochrome
c-dependent activation of procaspase-3. |
|
|
| | |
| 25717 | HSPB1 | Protein | Homo sapiens-e | Decreases translocation | direct | DAXX | Protein | Homo sapiens-e | | | HSP27 also prevents the translocation of Daxx
from the nucleus to the cytoplasm | | | |
Interaction id | 25717 | |
MOLECULE A | |
Id | 3315 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 1616 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Decreases translocation (
direct ) | |
Pathway | Response to Stress :Response to Heat | |
Experimental location and method | - sub cellular::Nucleus to the cytoplasm
| |
References | |
PubMed Id | 11193028 | |
Author | Charette SJ, Landry J | |
Title | The interaction of HSP27 with Daxx identifies a potential
regulatory role of HSP27 in Fas-induced apoptosis. |
|
|
| |
|
d: for diseases
