| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 2160 | BDNF | Protein | Homo sapiens-e | Increases expression | indirect | SYP | Protein | Homo sapiens-e | |
| BDNF also increased the levels of the vesicle
proteins synaptophysin, synaptobrevin, and synaptotagmin,
without affecting the presynaptic membrane proteins syntaxin
and SNAP-25, or the vesicle-binding protein synapsin-I. | |
| |
Interaction id | 2160 | |
MOLECULE A | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 6855 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Transmembrane Receptor Protein Tyrosine Kinase
Signaling Pathway:Brain-Derived Neurotrophic Factor
Receptor Signaling Pathway | |
References | |
PubMed Id | 11483592 | |
Author | Tartaglia N, Du J, Tyler WJ, Neale E, Pozzo-Miller L, Lu B | |
Title | Protein synthesis-dependent and -independent regulation of
hippocampal synapses by brain-derived neurotrophic factor. |
|
|
|
|
|
| 3819 | BDNF | Protein | Homo sapiens-e | Increases activity | direct | NTRK2 | Protein | Homo sapiens-e | |
| This signal has been shown to promote the
granule cell survival through BDNF-mediated TrkB activation,
leading to Purkinje cell differentiation by increasing the
granule-Purkinje cell interaction. | |
| |
Interaction id | 3819 | |
MOLECULE A | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 4915 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Transmembrane Receptor Protein Tyrosine Kinase
Signaling Pathway:Brain-Derived Neurotrophic Factor
Receptor Signaling Pathway | |
Experimental location and method | - cell::Cerebellar neuronal culture cells
| |
References | |
PubMed Id | 10884305 | |
Author | Hirai H, Launey T | |
Title | The regulatory connection between the activity of granule
cell NMDA receptors and dendritic differentiation of cerebellar
Purkinje cells. |
|
|
|
|
|
| 21555 | BDNF | Protein | Homo sapiens-e | Increases activity | indirect | AKT | Family | Homo sapiens-e | |
| BDNF and NMDA increased Akt phosphorylation
within 5 minutes but maximal activation by NMDA was observed
at 3 hours. | |
| |
Interaction id | 21555 | |
MOLECULE A | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | EZHsF00022 |
Type | Family |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Negative | | Description | LY294002, K252a |
|
| | Kinetics | | Mol B | | Conc | Time | Others | Comments | | <=5min
| | |
|
| |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Transmembrane receptor activity:Glial cell
line-derived neurotrophic factor receptor activity | |
Experimental location and method | - cell::Cerebellar granule cell neurons
| |
References | |
PubMed Id | 12373512 | |
Author | Zhu D, Lipsky RH, Marini AM | |
Title | Co-activation of the phosphatidylinositol-3-kinase/Akt
signaling pathway by N-methyl-D-aspartate and TrkB receptors in
cerebellar granule cell neurons. |
|
|
|
|
|
| 104736 | BDNF | Protein | Homo sapiens-e | Inhibits activity | indirect | GSK3B | Protein | Homo sapiens-e | |
| Here, we report that inhibition of ERK1/2
increased the basal activity of GSK3beta in cortical neurons
and that both ERK1/2 and PI3K were required for
brain-derived neurotrophic factor (BDNF) suppression of
GSK3beta activity. | |
| |
Interaction id | 104736 | |
MOLECULE A | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 2932 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits activity (
indirect ) | |
Pathway | Transmembrane Receptor Protein Tyrosine Kinase
Signaling Pathway:Brain-Derived Neurotrophic Factor
Receptor Signaling PathwayProtein kinase cascade:MAPK/ERK signaling pathwayApoptosisIntracellular Signaling
Cascade:Phosphatidylinositol 3-Kinase Mediated Signaling | |
Experimental location and method |
| |
References | |
PubMed Id | 12393899 | |
Author | Hetman M, Hsuan SL, Habas A, Higgins MJ, Xia Z | |
Title | ERK1/2 antagonizes glycogen synthase kinase-3beta-induced
apoptosis in cortical neurons. |
|
|
|
|
|
| 120146 | BDNF | Protein | Homo sapiens-e | Increases activity | indirect | Phosphoinositide-3-kinase | Multi subunit | Homo sapiens-e | |
| These results indicate that the activation of
TrkB by BDNF induces the activation of PI3-K via IRS-1 and
-2 rather than by a direct interaction of TrkB with PI3-K in
cultured cortical neurons. | |
| |
Interaction id | 120146 | |
MOLECULE A | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | EZHsM00003 |
Type | Multi subunit |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Transmembrane Receptor Protein Tyrosine Kinase
Signaling Pathway:Brain-Derived Neurotrophic Factor
Receptor Signaling Pathway | |
Experimental location and method |
| |
References | |
PubMed Id | 9374521 | |
Author | Yamada M, Ohnishi H, Sano S, Nakatani A, Ikeuchi T,
Hatanaka H | |
Title | Insulin receptor substrate (IRS)-1 and IRS-2 are
tyrosine-phosphorylated and associated with phosphatidylinositol
3-kinase in response to brain-derived neurotrophic factor in
cultured cerebral cortical neurons. |
|
|
|
|
|
| 185794 | BDNF | Protein | Homo sapiens-e | Decreases activity | indirect | Casp3 | Protein | Rattus norvegicus | |
| We measured the neurotoxicity of two
antipsychotic drug treatments, haloperidol and risperidone,
in primary cultured rat cortical neurons. / Treatment with
haloperidol also led the reduction of phosphorylation levels
of Akt, and activated caspase-3. / Moreover, brain-derived
neurotrophic factor (BDNF) reduced the caspase-3 activity
and protected neurons from haloperidol-induced apoptosis.
BDNF also reversed the reduced levels of phosphorylation of
Akt caused by treatment with haloperidol. | |
| |
Interaction id | 185794 | |
MOLECULE A | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 25402 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Decreases activity (
indirect ) | |
Pathway | Transmembrane Receptor Protein Tyrosine Kinase
Signaling Pathway:Brain-Derived Neurotrophic Factor
Receptor Signaling PathwayApoptosis:Caspase Activation | |
Experimental location and method | - species::Rat
- condition::Haloperidol treated cells
- cell::Cortical neurons
| |
References | |
PubMed Id | 15168214 | |
Author | Ukai W, Ozawa H, Tateno M, Hashimoto E, Saito T | |
Title | Neurotoxic potential of haloperidol in comparison with
risperidone: implication of Akt-mediated signal changes by haloperidol. |
|
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Regulator