| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 21474 | NF-kappa-B | Multi subunit | Homo sapiens-e | Decreases activity | direct | PPARG | Protein | Homo sapiens-e | | | Unlike suppression of the PPAR-gamma
transactivation function by mitogen-activated protein
kinase-induced growth factor signalling through
phosphorylation of the A/B domain, NF-kappaB blocks
PPAR-gamma binding to DNA by forming a complex with
PPAR-gamma and its AF-1-specific co-activator PGC-2. | | | |
Interaction id | 21474 | |
MOLECULE A | |
Id | TRHsM00001 |
Type | Multi subunit |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5468 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Decreases activity (
direct ) | |
Pathway | Protein Kinase Cascade:I-Kappab Kinase/Nf-Kappab CascadeCell Differentiation | |
Experimental location and method | - cell::Pluripotent mesenchymal stem cells
| |
References | |
PubMed Id | 12598905 | |
Author | Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S,
Yamauchi T, Kadowaki T, Takeuchi Y, Shibuya H, Gotoh Y,
Matsumoto K, Kato S | |
Title | Cytokines suppress adipogenesis and PPAR-gamma function
through the TAK1/TAB1/NIK cascade. |
|
|
| |
|
d: for diseases
