| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 87378 | Hydrogen peroxide | Small molecule | Small molecule | Increases activity | indirect | MAP3K5 | Protein | Homo sapiens-e | | | Treatment of cells with N-acetyl-L-cysteine
also inhibited serum withdrawal-, TNF-alpha- and hydrogen
peroxide-induced activation of ASK1 as well as apoptosis. | | | |
Interaction id | 87378 | |
MOLECULE A | |
Id | 7722-84-1 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 4217 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Negative | | Description | Acetylcysteine |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | | |
References | |
PubMed Id | 9564042 | |
Author | Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada
Y, Kawabata M, Miyazono K, Ichijo H | |
Title | Mammalian thioredoxin is a direct inhibitor of apoptosis
signal-regulating kinase (ASK) 1. |
|
|
| | |
| 181654 | MAP3K5 | Protein | Homo sapiens-e | Increases activity | direct | MAP2K4 | Protein | Homo sapiens-e | | | A conserved docking site, termed DVD, is
found in the mammalian MAP kinase kinases (MAPKKs) belonging
to the three major subfamilies, namely MEK1, MKK4/7, and
MKK3/6. The DVD sites bind to their specific upstream MAP
kinase kinase kinases (MAPKKKs), including MTK1 (MEKK4),
ASK1, TAK1, TAO2, MEKK1, and Raf-1. DVD site is a stretch of
about 20 amino acids immediately on the C-terminal side of
the MAPKK catalytic domain. Mutations in the DVD site
strongly inhibited MAPKKs from binding to, and being
activated by, their specific MAPKKKs, both in vitro and in vivo. | | | |
Interaction id | 181654 | |
MOLECULE A | |
Id | 4217 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 6416 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Protein kinase cascade:MAPK/ERK signaling pathway | |
Experimental location and method | - Experimental method::Mutation analysis
| |
Comments | |
Property | | Mutated molecule:MAP2K4 |
Domain_motif_site_residue | | [C-TER DOMAIN:Catalytic
domain(REGION:Stretch of 20 amino acids DVD site)](6416) |
| |
References | |
PubMed Id | 15866172 | |
Author | Takekawa M, Tatebayashi K, Saito H | |
Title | Conserved docking site is essential for activation of
mammalian MAP kinase kinases by specific MAP kinase kinase kinases. |
|
|
| | |
| 232127 | MAP3K5 | Protein | Homo sapiens | Increases phosphorylation | indirect | HIPK1 | Protein | Homo sapiens | | | Role of the ASK1-SEK1-JNK1-HIPK1 signal in
Daxx trafficking and ASK1 oligomerization. / Overexpression
of JNK binding domain inhibited glucose deprivation-induced
JNK1 activation, relocalization of Daxx from the nucleus to
the cytoplasm, and apoptosis signal-regulating kinase 1
(ASK1) oligomerization in human prostate adenocarcinoma
DU-145 cells. / Studies from in vivo labeling and immune
complex kinase assay demonstrated that phosphorylation of
Daxx occurred during glucose deprivation, and its
phosphorylation was mediated through the
ASK1-SEK1-JNK1-HIPK1 signal transduction pathway. / Taken
together, these results show that glucose deprivation
activates the ASK1-SEK1-JNK1-HIPK1 pathway, and the
activated HIPK1 is probably involved in the relocalization
of Daxx from the nucleus to the cytoplasm. | | | |
Interaction id | 232127 | |
MOLECULE A | |
Id | 4217 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 204851 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases phosphorylation (
indirect ) | |
Experimental location and method | - species::Human
- condition::Glucose deprivation
- cell::DU145 cells
| |
References | |
PubMed Id | 12968034 | |
Author | Song JJ, Lee YJ | |
Title | Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking
and ASK1 oligomerization. |
|
|
| |
|
d: for diseases
Regulator