| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 232093 | LYL1 | Protein | Homo sapiens-e | Bind | direct | NFKB1 | Protein | Homo sapiens-e | | | A yeast two-hybrid system was used to
identify proteins that specifically interact with LYL1 and
might mediate its activities. We found that p105, the
precursor of NF-kappaB1 p50, was the major LYL1-interacting
protein in this system. The association between LYL1 and
p105 was confirmed both in vitro and in vivo in mammalian
cells. Biochemical studies indicated that the interaction
was mediated by the bHLH motif of LYL1 and the ankyrin-like
motifs of p105. Ectopic expression of LYL1 in a human T cell
line caused a significant decrease in NF-kappaB-dependent
transcription, associated with a reduced level of NF-kappaB1 proteins. | | | |
Interaction id | 232093 | |
MOLECULE A | |
Id | 4066 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 4790 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Bind (
direct ) | |
Experimental location and method | - Experimental method::Yeast two hybrid assay
- cell::Mammalian cells
| |
Comments | |
Property | | p105 form of NFKB1 |
Domain_motif_site_residue | | (PF00010)(4066) |
General | | LYL1 binds to NFKB1 and makes it unavilable for
NF-kappaB activity |
| |
References | |
PubMed Id | 10023675 | |
Author | Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J,
Mathieu-Mahul D | |
Title | Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. |
|
|
| | |
| 232123 | LYL1 | Protein | Homo sapiens-e | Inhibits activity | indirect | NF-kappa-B | Multi subunit | Homo sapiens | | | Ectopic expression of LYL1 in a human T cell
line caused a significant decrease in NF-kappaB-dependent
transcription, associated with a reduced level of NF-kappaB1 proteins. | | | |
Interaction id | 232123 | |
MOLECULE A | |
Id | 4066 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | TRHsM00001 |
Type | Multi subunit |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits activity (
indirect ) | |
Experimental location and method | - species::Human
- cell::T-Lymphocytes
| |
References | |
PubMed Id | 10023675 | |
Author | Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J,
Mathieu-Mahul D | |
Title | Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. |
|
|
| |
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Structure