| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 232055 | PDCD5 | Protein | Homo sapiens-e | Increases activity | indirect | CASP3 | Protein | Homo sapiens | |
| Decreased expression of PDCD5 has been
detected in various human carcinomas. Here we describe that
one potent short interfering RNA (siRNA) against the PDCD5
(siPDCD5) specifically inhibits the expression of PDCD5 at
both the mRNA and protein level. / Furthermore, we also show
that siPDCD5 inhibited both caspase-3 activity and
procaspase-3 cleavage. | |
| |
Interaction id | 232055 | |
MOLECULE A | |
Id | 9141 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | disease: :Carcinomaexpression: :High | |
MOLECULE B | |
Id | 836 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Disease Details | | |
Experimental location and method | - Experimental method::Transcript silencing
| |
Comments | |
Property | | Transcript silenced molecule:PDCD5 |
| |
References | |
PubMed Id | 16374546 | |
Author | Chen LN, Wang Y, Ma DL, Chen YY | |
Title | Short interfering RNA against the PDCD5 attenuates cell
apoptosis and caspase-3 activity induced by Bax overexpression. |
|
|
|
|
|
| 232056 | PDCD5 | Protein | Homo sapiens-e | Increases pro-cleavage | indirect | CASP3 | Protein | Homo sapiens-e | |
| Decreased expression of PDCD5 has been
detected in various human carcinomas. Here we describe that
one potent short interfering RNA (siRNA) against the PDCD5
(siPDCD5) specifically inhibits the expression of PDCD5 at
both the mRNA and protein level. / Furthermore, we also show
that siPDCD5 inhibited both caspase-3 activity and
procaspase-3 cleavage. | |
| |
Interaction id | 232056 | |
MOLECULE A | |
Id | 9141 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | disease: :Carcinomaexpression: :High | |
MOLECULE B | |
Id | 836 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases pro-cleavage (
indirect ) | |
Disease Details | | |
Experimental location and method | - Experimental method::Transcript silencing
| |
Comments | |
Property | | Transcript silenced molecule:PDCD5;Pro CASP3 |
| |
References | |
PubMed Id | 16374546 | |
Author | Chen LN, Wang Y, Ma DL, Chen YY | |
Title | Short interfering RNA against the PDCD5 attenuates cell
apoptosis and caspase-3 activity induced by Bax overexpression. |
|
|
|
|
|
| 232060 | PDCD5 | Protein | Homo sapiens-e | Increases release | indirect | CYCS | Protein | Homo sapiens-e | |
| Decreased expression of PDCD5 has been
detected in various human carcinomas. Here we describe that
one potent short interfering RNA (siRNA) against the PDCD5
(siPDCD5) specifically inhibits the expression of PDCD5 at
both the mRNA and protein level. / Suppressed expression of
PDCD5 attenuates the release of cytochrome c from
mitochondria to cytosol induced by Bax overexpression. | |
| |
Interaction id | 232060 | |
MOLECULE A | |
Id | 9141 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | disease: :Carcinomaexpression: :High | |
MOLECULE B | |
Id | 54205 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases release (
indirect ) | |
Disease Details | | |
Experimental location and method | - Experimental method::Transcript silencing
- condition::BAX induced CYCS release
- sub cellular::From mitochondria to cytosol
| |
Comments | |
Property | | Transcript silenced molecule:PDCD5 |
| |
References | |
PubMed Id | 16374546 | |
Author | Chen LN, Wang Y, Ma DL, Chen YY | |
Title | Short interfering RNA against the PDCD5 attenuates cell
apoptosis and caspase-3 activity induced by Bax overexpression. |
|
|
|
|
|
| 232064 | PDCD5 | Protein | Homo sapiens-e | Increases translocation | indirect | BAX | Protein | Homo sapiens-e | |
| Decreased expression of PDCD5 has been
detected in various human carcinomas. Here we describe that
one potent short interfering RNA (siRNA) against the PDCD5
(siPDCD5) specifically inhibits the expression of PDCD5 at
both the mRNA and protein level. / Suppressed expression of
PDCD5 attenuates the release of cytochrome c from
mitochondria to cytosol induced by Bax overexpression. This
phenomenon is accompanied by the reduced translocation of
Bax from the cytosol to mitochondria. | |
| |
Interaction id | 232064 | |
MOLECULE A | |
Id | 9141 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | disease: :Carcinomaexpression: :High | |
MOLECULE B | |
Id | 581 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases translocation (
indirect ) | |
Disease Details | | |
Experimental location and method | - Experimental method::Transcript silencing
- sub cellular::From cytosol to mitochondria
| |
Comments | |
Property | | Transcript silenced molecule:PDCD5 |
| |
References | |
PubMed Id | 16374546 | |
Author | Chen LN, Wang Y, Ma DL, Chen YY | |
Title | Short interfering RNA against the PDCD5 attenuates cell
apoptosis and caspase-3 activity induced by Bax overexpression. |
|
|
|
|
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