| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 55723 | TTF1 | Protein | Homo sapiens-e | Bind | direct | ERBB2 | DNA | Homo sapiens-e | | | TTF-1 binds to and transactivates the erbB-2
and LHRH promoters, but represses transcription of the
preproenkephalin gene. | | | |
Interaction id | 55723 | |
MOLECULE A | |
Id | 7270 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 2064 |
Type | DNA |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Bind (
direct ) | |
Pathway | | |
References | |
PubMed Id | 11161473 | |
Author | Lee BJ, Cho GJ, Norgren RB Jr, Junier MP, Hill DF, Tapia V,
Costa ME, Ojeda SR | |
Title | TTF-1, a homeodomain gene required for diencephalic
morphogenesis, is postnatally expressed in the neuroendocrine
brain in a developmentally regulated and cell-specific fashion. |
|
|
| | |
| 55725 | TTF1 | Protein | Homo sapiens-e | Increases activity | direct | ERBB2 | DNA | Homo sapiens-e | | | TTF-1 binds to and transactivates the erbB-2
and LHRH promoters, but represses transcription of the
preproenkephalin gene. | | | |
Interaction id | 55725 | |
MOLECULE A | |
Id | 7270 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 2064 |
Type | DNA |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | | |
References | |
PubMed Id | 11161473 | |
Author | Lee BJ, Cho GJ, Norgren RB Jr, Junier MP, Hill DF, Tapia V,
Costa ME, Ojeda SR | |
Title | TTF-1, a homeodomain gene required for diencephalic
morphogenesis, is postnatally expressed in the neuroendocrine
brain in a developmentally regulated and cell-specific fashion. |
|
|
| | |
| 232053 | ERBB2 | Protein | Homo sapiens-e | Increases expression | indirect | Tnfaip2 | Protein | Mus musculus | | | ERBB2 amplification and overexpression have
been found in a number of human cancers, including breast,
ovary and kidney carcinoma. / The differential gene
expression profile of ERBB2-transfected and wild-type mouse
fibroblasts was monitored employing DNA microarrays.
Regulated expression of selected genes was verified by
RT-PCR and validated by Western blot analysis. / ERBB2
overexpression suppresses the transcription of
antiangiogenic factors (e.g., Sparc, Timp3, Serpinf1) but
induces expression of angiogenic factors (e.g., Klf5,
Tnfaip2, Sema3c). | | | |
Interaction id | 232053 | |
MOLECULE A | |
Id | 2064 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | disease: :Breast Neoplasms:Ovarian
Neoplasms:Kidney Neoplasmsexpression: :High | |
MOLECULE B | |
Id | 21928 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Morphogenesis:Angiogenesis | |
Disease Details | | disease: :Breast Neoplasms:Ovarian Neoplasms:Kidney Neoplasms |
| |
Experimental location and method | - Experimental method::Blotting, Western
- Experimental method::Microarray Analysis
- Experimental method::Polymerase Chain Reaction
- species::Mouse
- cell::Fibroblasts
| |
References | |
PubMed Id | 15609325 | |
Author | Beckers J, Herrmann F, Rieger S, Drobyshev AL, Horsch M,
Hrabe de Angelis M, Seliger B | |
Title | Identification and validation of novel ERBB2 (HER2, NEU)
targets including genes involved in angiogenesis. |
|
|
| |
|
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