| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 232053 | ERBB2 | Protein | Homo sapiens-e | Increases expression | indirect | Tnfaip2 | Protein | Mus musculus | | | ERBB2 amplification and overexpression have
been found in a number of human cancers, including breast,
ovary and kidney carcinoma. / The differential gene
expression profile of ERBB2-transfected and wild-type mouse
fibroblasts was monitored employing DNA microarrays.
Regulated expression of selected genes was verified by
RT-PCR and validated by Western blot analysis. / ERBB2
overexpression suppresses the transcription of
antiangiogenic factors (e.g., Sparc, Timp3, Serpinf1) but
induces expression of angiogenic factors (e.g., Klf5,
Tnfaip2, Sema3c). | | | |
Interaction id | 232053 | |
MOLECULE A | |
Id | 2064 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | disease: :Breast Neoplasms:Ovarian
Neoplasms:Kidney Neoplasmsexpression: :High | |
MOLECULE B | |
Id | 21928 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Morphogenesis:Angiogenesis | |
Disease Details | | disease: :Breast Neoplasms:Ovarian Neoplasms:Kidney Neoplasms |
| |
Experimental location and method | - Experimental method::Blotting, Western
- Experimental method::Microarray Analysis
- Experimental method::Polymerase Chain Reaction
- species::Mouse
- cell::Fibroblasts
| |
References | |
PubMed Id | 15609325 | |
Author | Beckers J, Herrmann F, Rieger S, Drobyshev AL, Horsch M,
Hrabe de Angelis M, Seliger B | |
Title | Identification and validation of novel ERBB2 (HER2, NEU)
targets including genes involved in angiogenesis. |
|
|
| | |
| 232089 | TNF | Protein | Homo sapiens-e | Increases expression | indirect | TNFAIP2 | RNA | Homo sapiens | | | We utilized cDNA representational difference
analysis to identify the genes in which expression is
induced by the proinflammatory cytokines tumor necrosis
factor-alpha and interleukin-1beta in primary human
bronchial epithelial cells and hence are relevant to airway
inflammation. Hybridization of the subtraction product to
arrayed cDNAs indicated that known tumor necrosis
factor-alpha- and interleukin-1beta-inducible genes such as
B94, Zfp36, and regulated on activation normal T cell
expressed and secreted were represented, confirming the
success of the subtraction experiment. | | | |
Interaction id | 232089 | |
MOLECULE A | |
Id | 7124 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 7127 |
Type | RNA |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Immune Response:Inflammatory Response | |
Experimental location and method | - Experimental method::Subtraction hybridization
- species::Human
- cell::Primary epithelial cells
- organ / tissue::Bronchi
| |
References | |
PubMed Id | 11290506 | |
Author | Cooper P, Potter S, Mueck B, Yousefi S, Jarai G | |
Title | Identification of genes induced by inflammatory cytokines in
airway epithelium. |
|
|
| | |
| 232091 | IL1B | Protein | Homo sapiens-e | Increases expression | indirect | TNFAIP2 | RNA | Homo sapiens | | | We utilized cDNA representational difference
analysis to identify the genes in which expression is
induced by the proinflammatory cytokines tumor necrosis
factor-alpha and interleukin-1beta in primary human
bronchial epithelial cells and hence are relevant to airway
inflammation. Hybridization of the subtraction product to
arrayed cDNAs indicated that known tumor necrosis
factor-alpha- and interleukin-1beta-inducible genes such as
B94, Zfp36, and regulated on activation normal T cell
expressed and secreted were represented, confirming the
success of the subtraction experiment. | | | |
Interaction id | 232091 | |
MOLECULE A | |
Id | 3553 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 7127 |
Type | RNA |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Immune Response:Inflammatory Response | |
Experimental location and method | - Experimental method::Subtraction hybridization
- species::Human
- cell::Primary epithelial cells
- organ / tissue::Bronchi
| |
References | |
PubMed Id | 11290506 | |
Author | Cooper P, Potter S, Mueck B, Yousefi S, Jarai G | |
Title | Identification of genes induced by inflammatory cytokines in
airway epithelium. |
|
|
| |
|
d: for diseases
Disease