| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 224559 | Cimetidine | Small molecule | Small molecule | Inhibits expression | indirect | Tnf | Protein | Mus musculus | | | To investigate the effects of cocaine on
myocardial injuries and cardiac P450 expression, BALB/c mice
were injected daily intraperitoneally with cocaine (30
mg/kg) or cocaine plus pretreatment of P450 inhibitors for
14 days. / Tumor necrosis factor-alpha (TNF-alpha) content
and creatine phosphokinase (CPK) activity in mice hearts and
serums were significantly increased after long-term
treatment with cocaine. Pretreatment with the P450
inhibitor, cimetidine (Cime, 50 mg/kg) or metyrapone (Mety,
40 mg/kg) abolished or significantly attenuated the effects
of cocaine on TNF-alpha and CPK activity. | | | |
Interaction id | 224559 | |
MOLECULE A | |
Id | 51481-61-9 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 21926 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | | Mol A | | Conc | Time | Others | Comments | 50mg/kg
| | | Pretreatment to Cocaine
|
| | Mol B | | Conc | Time | Others | Comments | | | | Significant decrease
|
|
| |
|
General Information |
Interaction term | Inhibits expression (
indirect ) | |
Experimental location and method | - species::BALB/c Mouse
- condition::Cocaine treated mouse
- organ / tissue::Heart
| |
Comments | |
General | | This was also seen in serum |
| |
References | |
PubMed Id | 11856816 | |
Author | Wang JF, Yang Y, Sullivan MF, Min J, Cai J, Zeldin DC, Xiao
YF, Morgan JP | |
Title | Induction of cardiac cytochrome p450 in cocaine-treated mice. |
|
|
| |
|
d: for diseases
