| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 166526 | Suramin | Small molecule | Small molecule | Inhibits level | indirect | Calcium | Small molecule | Small molecule | | | Suramin inhibits beta-bungarotoxin-induced
activation of N-methyl-D-aspartate receptors and
cytotoxicity in primary neurons. / In conclusion, the novel
finding of this study was that a polypeptide beta-BuTX
exerted a potent cytotoxic effect through sequential events,
including activating NMDA receptors followed by increasing
[Ca2+]i, ROS production, and impaired mitochondrial energy
metabolism. Suramin, clinically used as a trypanocidal
agent, was an effective antagonist against beta-BuTX. | | | |
Interaction id | 166526 | |
MOLECULE A | |
Id | 145-63-1 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | Calcium |
Type | Small molecule |
Species | Small molecule | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits level (
indirect ) | |
Experimental location and method | - condition::beta-bungarotoxin treated cells
- cell::Primary neurons
| |
References | |
PubMed Id | 12758059 | |
Author | Tseng WP, Lin-Shiau SY | |
Title | Suramin inhibits beta-bungarotoxin-induced activation of
N-methyl-D-aspartate receptors and cytotoxicity in primary neurons. |
|
|
| | |
| 221383 | Genistein | Small molecule | Small molecule | Inhibits mobilization | indirect | Calcium | Small molecule | Small molecule | | | HIV-1 Tat through phosphorylation of NMDA
receptors potentiates glutamate excitotoxicity. / Calcium
flux in cultured rat hippocampal neurons triggered by the
transient application of glutamate or NMDA was facilitated
by pre-exposure to Tat. / Facilitation of NMDA-triggered
calcium flux by Tat was reversed by inhibitors of tyrosine
kinase (genestein and herbimycin A) and by an inhibitor of
NMDA receptor function (zinc). Tat increased 32P
incorporation into NMDA receptor subunits NR2A and NR2B and
this effect was blocked by genestein. | | | |
Interaction id | 221383 | |
MOLECULE A | |
Id | 446-72-0 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | Calcium |
Type | Small molecule |
Species | Small molecule | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits mobilization (
indirect ) | |
Experimental location and method | - species::Rat
- condition::N-Methyl-D-aspartate induced
mobilization of Calcium
- cell::Neurons
- organ / tissue::Hippocampus
| |
References | |
PubMed Id | 11483648 | |
Author | Haughey NJ, Nath A, Mattson MP, Slevin JT, Geiger JD | |
Title | HIV-1 Tat through phosphorylation of NMDA receptors
potentiates glutamate excitotoxicity. |
|
|
| |
|
d: for diseases
