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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
221383GenisteinSmall moleculeSmall moleculeInhibits mobilizationindirectCalciumSmall moleculeSmall molecule
HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. / Calcium flux in cultured rat hippocampal neurons triggered by the transient application of glutamate or NMDA was facilitated by pre-exposure to Tat. / Facilitation of NMDA-triggered calcium flux by Tat was reversed by inhibitors of tyrosine kinase (genestein and herbimycin A) and by an inhibitor of NMDA receptor function (zinc). Tat increased 32P incorporation into NMDA receptor subunits NR2A and NR2B and this effect was blocked by genestein.