| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 219786 | Aspirin | Small molecule | Small molecule | Inhibits expression | indirect | TNF | Protein | Homo sapiens | | | Alcoholic liver disease (ALD) is one of the
most common liver diseases in the world. Increased levels of
proinflammatory cytokines, including interleukin-1beta
(IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), have
been correlated with the patients affected by ALD. / In this
study, we demonstrated that acetaldehyde, the metabolic
product of ethanol, was able to induce IL-1beta and
TNF-alpha production in HepG2 cells. / However, the
NF-kappaB inhibitors, such as aspirin, cyclosporin A and
dexamethasone, inhibited both the acetaldehyde-induced
NF-kappaB activity and the induced cytokine production. | | | |
Interaction id | 219786 | |
MOLECULE A | |
Id | 50-78-2 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 7124 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | disease: :Liver Diseases, Alcoholicexpression: :High | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits expression (
indirect ) | |
Pathway | Protein Kinase Cascade:I-Kappab Kinase/Nf-Kappab Cascade | |
Disease Details | | disease: :Liver Diseases, Alcoholic |
| |
Experimental location and method | - species::Human
- condition::Acetaldehyde induced
expression of TNF
- cell::HEPG2 cells
| |
References | |
PubMed Id | 16132116 | |
Author | Hsiang CY, Wu SL, Cheng SE, Ho TY | |
Title | Acetaldehyde-induced interleukin-1beta and tumor necrosis
factor-alpha production is inhibited by berberine through
nuclear factor-kappaB signaling pathway in HepG2 cells. |
|
|
| |
|
d: for diseases
Disease