| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 219675 | Glivec | Small molecule | Small molecule | Decreases expression | indirect | TNF | Protein | Homo sapiens | | | Imatinib mesylate suppresses cytokine
synthesis by activated CD4 T cells of patients with chronic
myelogenous leukemia. / As cytokines are required for T-cell
proliferation, we investigated the effects of IM on cytokine
synthesis by T cells of CML patients by assessing cytokine
synthesis by activated CD4+ and CD8+ T cells in vitro. The
activation of T cells in the whole blood of IM-treated
patients (CML-IM) with Staphylococcus enterotoxin B resulted
in significantly lower percentages of CD4+ T cells that
synthesized interleukin 2 (P = 0.017), interferon-gamma (P =
0.010), and tumor necrosis factor-alpha (P = 0.009) than did
the activated T cells of control subjects. | | | |
Interaction id | 219675 | |
MOLECULE A | |
Id | 220127-57-1 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 7124 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Decreases expression (
indirect ) | |
Pathway | Response to Stimulus:Response to Drug | |
Disease Details | | disease: :Leukemia, Myeloid, Chronic |
| |
Experimental location and method | - species::Human
- condition::Enterotoxin B,
staphylococcal induced expression of TNF in cells of
chronic myelogenous leukemia patients
- cell::CD4-Positive T-Lymphocytes
| |
References | |
PubMed Id | 16151467 | |
Author | Gao H, Lee BN, Talpaz M, Donato NJ, Cortes JE, Kantarjian
HM, Reuben JM | |
Title | Imatinib mesylate suppresses cytokine synthesis by activated
CD4 T cells of patients with chronic myelogenous leukemia. |
|
|
| |
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