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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
218387L-GlutamineSmall moleculeSmall moleculeDecreases releaseindirectTnfProteinRattus norvegicus
Glutamine (GLN) has been shown to attenuate cytokine release from LPS-stimulated human peripheral blood mononuclear cells; however, the in vivo antiinflammatory effect of GLN in polymicrobial sepsis and ARDS is unknown. / Either 0.75 g/kg of GLN or saline placebo (SP) was administered to male rats 1 h after cecal ligation and puncture (CLP). / GLN treatment increased MKP-1 peptide expression and significantly attenuated TNF-alpha and IL-6 6 h after CLP. / The antiinflammatory effect of GLN was associated with attenuation of ARDS and mortality.
Disease