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Glutamine (GLN) has been shown to attenuate
cytokine release from LPS-stimulated human peripheral blood
mononuclear cells; however, the in vivo antiinflammatory
effect of GLN in polymicrobial sepsis and ARDS is unknown. /
Either 0.75 g/kg of GLN or saline placebo (SP) was
administered to male rats 1 h after cecal ligation and
puncture (CLP). / GLN treatment increased MKP-1 peptide
expression and significantly attenuated TNF-alpha and IL-6 6
h after CLP. / The antiinflammatory effect of GLN was
associated with attenuation of ARDS and mortality.