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Celecoxib and NS-398 enhance photodynamic
therapy by increasing in vitro apoptosis and decreasing in
vivo inflammatory and angiogenic factors. /
Photofrin-mediated PDT combined with either celecoxib or
NS-398 increased cytotoxicity and apoptosis in mouse BA
mammary carcinoma cells. / Administration of celecoxib or
NS-398 attenuated tissue levels of prostaglandin E2 and
vascular endothelial growth factor induced by PDT in treated
tumors and also decreased the expression of proinflammatory
mediators interleukin-1beta and tumor necrosis factor-alpha.