| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 3819 | BDNF | Protein | Homo sapiens-e | Increases activity | direct | NTRK2 | Protein | Homo sapiens-e | | | This signal has been shown to promote the
granule cell survival through BDNF-mediated TrkB activation,
leading to Purkinje cell differentiation by increasing the
granule-Purkinje cell interaction. | | | |
Interaction id | 3819 | |
MOLECULE A | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 4915 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Transmembrane Receptor Protein Tyrosine Kinase
Signaling Pathway:Brain-Derived Neurotrophic Factor
Receptor Signaling Pathway | |
Experimental location and method | - cell::Cerebellar neuronal culture cells
| |
References | |
PubMed Id | 10884305 | |
Author | Hirai H, Launey T | |
Title | The regulatory connection between the activity of granule
cell NMDA receptors and dendritic differentiation of cerebellar
Purkinje cells. |
|
|
| | |
| 215773 | NTRK2 | Protein | Homo sapiens | Increases activity | direct | Phosphoinositide-3-kinase | Multi subunit | Homo sapiens | | | Deprenyl increased the expression of HO-1,
PrxI, TrxI, TrxRxI, gammaGCS, and p62/A170 in SH-SY5Y cells.
/ Indeed, furthermore, neurotrophin receptor TrkB was
identified as an upstream signal for PI3K-Nrf2 activation by
deprenyl. These results suggest that the cytoprotective
effect of deprenyl is, in part, dependent on Nrf2-mediated
induction of antioxidative proteins, suggesting that
activation of the PI3K-Nrf2 system may be a useful
therapeutic strategy for PD. | | | |
Interaction id | 215773 | |
MOLECULE A | |
Id | 4915 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | EZHsM00003 |
Type | Multi subunit |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Response to Stimulus:Response to Drug | |
Disease Details | | disease: :Parkinson Disease |
| |
Experimental location and method | - species::Human
- condition::Deprenyl treated cells
- cell::SHSY5Y cells
| |
References | |
PubMed Id | 16325767 | |
Author | Nakaso K, Nakamura C, Sato H, Imamura K, Takeshima T,
Nakashima K | |
Title | Novel cytoprotective mechanism of anti-parkinsonian drug
deprenyl: PI3K and Nrf2-derived induction of antioxidative proteins. |
|
|
| |
|
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