| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 71574 | CCL2 | Protein | Homo sapiens-e | Increases activity | indirect | MAPK1 | Protein | Homo sapiens | | | MCP-1 stimulates, with distinct time courses,
extracellular signal-related kinases (ERK1 and ERK2) and
stress-activated protein kinases (SAPK1/JNK1 and SAPK2/p38). | | | |
Interaction id | 71574 | |
MOLECULE A | |
Id | 6347 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5594 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Negative | | Description | Pertussis toxin |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling PathwayCell migration | |
Experimental location and method | - species::Human
- cell::MonoMac6 cells
| |
References | |
PubMed Id | 11154209 | |
Author | Cambien B, Pomeranz M, Millet MA, Rossi B, Schmid-Alliana A | |
Title | Signal transduction involved in MCP-1-mediated monocytic
transendothelial migration. |
|
|
| | |
| 148222 | Map2k2 | Protein | Mus musculus | Increases activity | direct | Mapk1 | Protein | Mus musculus | | | Estradiol-induced phosphorylation of ERK1/2
in explants of the mouse cerebral cortex: the roles of heat
shock protein 90 (Hsp90) and MEK2. / Surprisingly, MEK2 but
not MEK1 was the principal mediator of estradiol-induced
activation of ERK. Our data demonstrate the requirement for
Hsp90 in estrogen-induced activation of ERK1 and ERK2 by
MEK2 in the developing mouse cerebral cortex and also
provide insight into alternative mechanisms by which
estradiol may influence cytoplasmic and nuclear events in
responsive neurons via the MAP kinase cascade. | | | |
Interaction id | 148222 | |
MOLECULE A | |
Id | 26396 |
Type | Protein |
Species | Mus musculus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 26413 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Intracellular Receptor-Mediated Signaling
Pathway:Estrogen Receptor Signaling PathwayProtein kinase cascade:MAPK/ERK signaling pathway | |
Experimental location and method | - species::Mouse
- condition::Estradiol-17beta treated
cerebral cortex explant
- organ / tissue::Cerebral cortex
| |
References | |
PubMed Id | 11748628 | |
Author | Setalo G Jr, Singh M, Guan X, Toran-Allerand CD | |
Title | Estradiol-induced phosphorylation of ERK1/2 in explants of
the mouse cerebral cortex: the roles of heat shock protein 90
(Hsp90) and MEK2. |
|
|
| | |
| 172891 | Map2k1 | Protein | Rattus norvegicus | Increases activity | direct | Mapk1 | Protein | Rattus norvegicus | | | Here we show that in C6 glioma cells,
transiently expressing the dominant-negative form of
c-Ha-Ras (Asn-17) abrogated IFN-gamma-induced ERK1 and ERK2
activation. Furthermore, PD98059, a specific MEK1 inhibitor,
also blocked this activation. These results indicate that
p21ras and MEK1 are required for IFN-gamma-induced ERK1 and
ERK2 activation. | | | |
Interaction id | 172891 | |
MOLECULE A | |
Id | 170851 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 116590 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Small GTPase Mediated Signal Transduction:RAS
Protein Signal TransductionCytokine And Chemokine Mediated Signaling
Pathway:IFN Gamma Signaling PathwayProtein kinase cascade:MAPK/ERK signaling pathway | |
Experimental location and method | - species::Rat
- condition::IFNG treated cells
- cell::C6 cells
| |
References | |
PubMed Id | 9180263 | |
Author | Nishiya T, Uehara T, Edamatsu H, Kaziro Y, Itoh H, Nomura Y | |
Title | Activation of Stat1 and subsequent transcription of inducible
nitric oxide synthase gene in C6 glioma cells is independent of
interferon-gamma-induced MAPK activation that is mediated by p21ras. |
|
|
| | |
| 210685 | CCR2 | Protein | Homo sapiens-e | Increases activity | indirect | MAPK1 | Protein | Homo sapiens | | | Within 2 min, the MCPs (1-4) elicited a rapid
and transient activation of MAPK in peripheral blood
mononuclear cells and in HEK-293 cells expressing CCR2b.
U0126, an inhibitor of MAPK-kinase (MEK) activation, not
only prevented extracellular signal-regulated kinase 1/2
(ERK1/2) activation but also significantly inhibited the
MCP-mediated chemotaxis. | | | |
Interaction id | 210685 | |
MOLECULE A | |
Id | 729230 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5594 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Positive | | Description | Ligand of molecule A:CCL2 |
| |
Regulation | Negative | |
| | Kinetics | | Mol B | | Conc | Time | Others | Comments | | | | Rapid
Transient
|
| | Regulators | | Name | Effect | Conc | Time | Others | Comments | | CCL2 | Stimulant | | 2min
| | |
|
| |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling Pathway | |
Interaction result | |
Other Resultant | | Chemotaxis |
| |
Experimental location and method | - species::Human
- cell::HEK293 cells
| |
Comments | |
General | | Also seen in peripheral blood mononuclear cells |
| |
References | |
PubMed Id | 11966759 | |
Author | Wain JH, Kirby JA, Ali S | |
Title | Leucocyte chemotaxis: Examination of mitogen-activated
protein kinase and phosphoinositide 3-kinase activation by
Monocyte Chemoattractant Proteins-1, -2, -3 and -4. |
|
|
| | |
| 212184 | MAPK1 | Protein | Homo sapiens | Increases activity | direct | CEBPB | Protein | Homo sapiens | | | The present study was undertaken to
investigate the effect of the HIV-1 tat gene on the
expression of inducible nitric-oxide synthase (iNOS) in
human U373MG astroglial cells and primary astroglia. / In
addition, we show that extracellular signal-regulated kinase
(ERK) but not that p38 mitogen-activated protein kinase
(MAPK) is involved in RSV-tat induced production of NO.
Interestingly, PD98059, an inhibitor of the ERK pathway, and
deltaERK2, a dominant-negative mutant of ERK2, inhibited
RSV-tat-induced production of NO through the inhibition of
C/EBPbeta but not that of NF-kappaB. | | | |
Interaction id | 212184 | |
MOLECULE A | |
Id | 5594 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 1051 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Protein kinase cascade:MAPK/ERK signaling pathwayImmune Response | |
Experimental location and method | - Experimental method::Dominant negative analysis
- species::Human
- condition::tat induced cells
- cell::U373MG;Primary Astrocytes
| |
Comments | |
Property | | Dominant negative molecule:MAPK1 |
| |
References | |
PubMed Id | 12167619 | |
Author | Liu X, Jana M, Dasgupta S, Koka S, He J, Wood C, Pahan K | |
Title | Human immunodeficiency virus type 1 (HIV-1) tat induces
nitric-oxide synthase in human astroglia. |
|
|
| | |
| 421535 | Mapk1 | Protein | Rattus norvegicus | Increases expression | indirect | Ptgs2 | Protein | Rattus norvegicus | | | Chronic ethanol intake induces brain damage,
although the mechanisms involved in this effect are not well
understood. / We used cerebral cortex from control and
chronic ethanol-fed rats, which received ethanol-liquid diet
for 5 months and cultured of astrocytes exposed to 75 mM
ethanol for 7 days. Our results demonstrate that chronic
ethanol treatment up-regulates iNOS, COX-2 and IL-1beta in
rat cerebral cortex and in cultured astrocytes. Under both
experimental conditions, up-regulation of these inflammatory
mediators and IL-1RI concomitantly occurs with the
stimulation of IRAK and MAP kinases, including ERK1/2, p-38
and JNK, which trigger the downstream activation of
oxidant-sensitive transcription factors NF-KB and AP-1. | | | |
Interaction id | 421535 | |
MOLECULE A | |
Id | 116590 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 29527 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Id | 64-17-5 : Ethanol |
Type | Small molecule |
Species | Small molecule | | Stimulate | | Attribute | Description | | Treatment time:
| Chronic |
|
|
Structure Details | |
Disease Details | disease: :Brain Damage, Chronicsignificance: :Inducer | | Kinetics | | Regulators | | Name | Effect | Conc | Time | Others | Comments | | Ethanol | Stimulant | 75mM
| 7day
| | In Astrocytes
Chronic treatment
|
|
| Regulators | | Name | Effect | Conc | Time | Others | Comments | | Ethanol | Stimulant | | 5month
| | Diet/water
Chronic treatment
In vivo
|
|
| |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Protein Kinase Cascade:I-Kappab Kinase/Nf-Kappab Cascade | |
Experimental location and method | - Location context::Interaction specific
- species::Rat
- organ / tissue::Cerebral Cortex
- Location context::Supporting evidence
- cell / cell line::Astrocytes
- primary::N
| |
References | |
PubMed Id | 15605983 | |
Author | Valles SL, Blanco AM, Pascual M, Guerri C | |
Title | Chronic ethanol treatment enhances inflammatory mediators and
cell death in the brain and in astrocytes. |
|
|
| |
|
d: for diseases
Regulator