| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 26212 | FAS | Protein | Homo sapiens-e | Increases translocation | indirect | DAXX | Protein | Homo sapiens-e | | | However, HSP27 blocked Fas-induced
translocation of Daxx from the nucleus to the cytoplasm and
Fas-induced Daxx- and Ask1-dependent apoptosis. | | | |
Interaction id | 26212 | |
MOLECULE A | |
Id | 355 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 1616 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Negative | | Description | Heat shock 27kDa protein |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Increases translocation (
indirect ) | |
Pathway | Apoptosis:Induction of Apoptosis Via Death Domain Receptors | |
Experimental location and method | - sub cellular::Nucleus to cytoplasm
| |
References | |
PubMed Id | 11003656 | |
Author | Charette SJ, Lavoie JN, Lambert H, Landry J | |
Title | Inhibition of Daxx-mediated apoptosis by heat shock protein 27. |
|
|
| | |
| 26213 | DAXX | Protein | Homo sapiens-e | Bind | direct | FAS | Protein | Homo sapiens-e | | | Here we show that phosphorylated dimers of
HSP27 interact with Daxx, a mediator of Fas-induced
apoptosis, preventing the interaction of Daxx with both Ask1
and Fas and blocking Daxx-mediated apoptosis. | | | |
Interaction id | 26213 | |
MOLECULE A | |
Id | 1616 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 355 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Negative | | Description | Heat shock 27kDa protein |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Bind (
direct ) | |
Pathway | Apoptosis:Induction of Apoptosis Via Death Domain Receptors | |
References | |
PubMed Id | 11003656 | |
Author | Charette SJ, Lavoie JN, Lambert H, Landry J | |
Title | Inhibition of Daxx-mediated apoptosis by heat shock protein 27. |
|
|
| | |
| 57364 | TNF | Protein | Homo sapiens-e | Increases expression | indirect | Fas | Protein | Mus musculus | | | Fas is constitutively expressed by primary
murine microglia at a low level and significantly
up-regulated by TNF-alpha or IFN-gamma stimulation. /
TNF-alpha and IFN-gamma induced Fas mRNA by approximately 20-fold. | | | |
Interaction id | 57364 | |
MOLECULE A | |
Id | 7124 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 14102 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | | Mol B | | Conc | Time | Others | Comments | | | aprx20fold
| Fas mRNA
|
|
| |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:TNF Signaling PathwayProtein Kinase Cascade:I-Kappab Kinase/Nf-Kappab Cascade | |
Experimental location and method | - species::Mouse
- cell::Microglial cells
| |
References | |
PubMed Id | 10640741 | |
Author | Lee SJ, Zhou T, Choi C, Wang Z, Benveniste EN | |
Title | Differential regulation and function of Fas expression on
glial cells. |
|
|
| | |
| 77850 | Activator protein 1 | Multi subunit | Homo sapiens-e | Increases activity | direct | FAS | DNA | Homo sapiens | | | Our present study identified an upstream
enhancer element (between nucleotide positions -862 and
-682) containing a GA-binding protein (GABP) site and a low
affinity activating protein-1 (AP-1)-binding site. T cell
activation increased the DNA binding of GABP and AP-1 to
this enhancer site. / Taken together, these results suggest
that the transcription factors GABP and AP-1 play a critical
role in the induction of Fas gene expression in T cell
antigen receptor.CD3-stimulated Jurkat cells. | | | |
Interaction id | 77850 | |
MOLECULE A | |
Id | TRHsM00014 |
Type | Multi subunit |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 355 |
Type | DNA |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Regulation of transcription | |
Experimental location and method | - Experimental method::Electrophoretic
Mobility Shift Assay
- species::Human
- condition::T cell antigen receptor and
CD3 complex stimulated jurkat cells
- cell::Jurkat cells
| |
Comments | |
Domain_motif_site_residue | | [US:-862 to -682](355) |
| |
References | |
PubMed Id | 10575005 | |
Author | Li XR, Chong AS, Wu J, Roebuck KA, Kumar A, Parrillo JE,
Rapp UR, Kimberly RP, Williams JW, Xu X | |
Title | Transcriptional regulation of Fas gene expression by
GA-binding protein and AP-1 in T cell antigen receptor.CD3
complex-stimulated T cells. |
|
|
| | |
| 83907 | Fas | Protein | Mus musculus | Increases phosphorylation | indirect | Nfkbia | Protein | Mus musculus | | | In fibroblast strains derived from these
embryos, the TNF receptors, Fas/Apo1, and DR3 were able to
activate the Jun N-terminal kinase and to trigger IkappaB
alpha phosphorylation and degradation. | | | |
Interaction id | 83907 | |
MOLECULE A | |
Id | 14102 |
Type | Protein |
Species | Mus musculus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 18035 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases phosphorylation (
indirect ) | |
Pathway | Apoptosis:Caspase Activation | |
Experimental location and method | - species::Mouse- Caspase 8 null embryos
- cell::Fibroblasts
| |
References | |
PubMed Id | 9729047 | |
Author | Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N,
Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC,
Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T,
Holtmann H, Lonai P, Wallach D | |
Title | Targeted disruption of the mouse Caspase 8 gene ablates cell
death induction by the TNF receptors, Fas/Apo1, and DR3 and is
lethal prenatally. |
|
|
| | |
| 83911 | Fas | Protein | Mus musculus | Increases degradation | indirect | Nfkbia | Protein | Mus musculus | | | In fibroblast strains derived from these
embryos, the TNF receptors, Fas/Apo1, and DR3 were able to
activate the Jun N-terminal kinase and to trigger IkappaB
alpha phosphorylation and degradation. | | | |
Interaction id | 83911 | |
MOLECULE A | |
Id | 14102 |
Type | Protein |
Species | Mus musculus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 18035 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases degradation (
indirect ) | |
Pathway | Apoptosis:Caspase ActivationCytokine And Chemokine Mediated Signaling
Pathway:TNF Signaling Pathway | |
Experimental location and method | - species::Mouse- Caspase 8 null embryos
- cell::Fibroblasts
| |
References | |
PubMed Id | 9729047 | |
Author | Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N,
Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC,
Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T,
Holtmann H, Lonai P, Wallach D | |
Title | Targeted disruption of the mouse Caspase 8 gene ablates cell
death induction by the TNF receptors, Fas/Apo1, and DR3 and is
lethal prenatally. |
|
|
| | |
| 210293 | FAS | Protein | Homo sapiens-e | Increases cleavage | indirect | CASP3 | Protein | Homo sapiens-e | | | In the present studies, we found that
stimulation of CD95 receptors, with either agonistic
antibody or CD95 ligand, resulted in the activation of
caspase-8, which in turn processed caspase-3 between its
large and small subunits. | | | |
Interaction id | 210293 | |
MOLECULE A | |
Id | 355 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 836 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Positive | | Description | Ligand of molecule A:FASLG |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Increases cleavage (
indirect ) | |
Pathway | Apoptosis:FAS Signaling Pathway | |
References | |
PubMed Id | 11801595 | |
Author | Sun XM, Bratton SB, Butterworth M, MacFarlane M, Cohen GM | |
Title | Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by
preventing mitochondrial release of Smac/DIABLO and subsequent
inactivation of X-linked inhibitor-of-apoptosis protein. |
|
|
| |
|
d: for diseases
Regulator