| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 62754 | Estradiol-17beta | Small molecule | Small molecule | Increases expression | indirect | Bdnf | Protein | Rattus norvegicus | |
| Young-adult rats responded to estrogen with
an increase in the expression of brain-derived neurotrophic
factor (BDNF) in the olfactory bulb and hlDBB, as well as
bulbar trkA and trkB receptors. | |
| |
Interaction id | 62754 | |
MOLECULE A | |
Id | 50-28-2 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 24225 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Intracellular Receptor-Mediated Signaling
Pathway:Estrogen Receptor Signaling Pathway | |
Experimental location and method | - species::Young-adult rats
- organ / tissue::Olfactory bulb,
Horizontal limb of the diagonal band of Broca
| |
References | |
PubMed Id | 11182481 | |
Author | Jezierski MK, Sohrabji F | |
Title | Neurotrophin expression in the reproductively senescent
forebrain is refractory to estrogen stimulation. |
|
|
|
|
|
| 68236 | Tacrolimus | Small molecule | Small molecule | Increases expression | indirect | Bdnf | RNA | Rattus norvegicus | |
| Upregulation of BDNF mRNA and protein level
in astrocytes exposed to FK506 may underlie neuroprotective
action of FK506. | |
| |
Interaction id | 68236 | |
MOLECULE A | |
Id | 104987-11-3 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 24225 |
Type | RNA |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Transmembrane Receptor Protein Tyrosine Kinase
Signaling Pathway:Brain-Derived Neurotrophic Factor
Receptor Signaling Pathway | |
Disease Details | | |
Experimental location and method | - species::Rat
- cell::Cortical astrocytes
| |
References | |
PubMed Id | 12676530 | |
Author | Zawadzka M, Kaminska B | |
Title | Immunosuppressant FK506 affects multiple signaling pathways
and modulates gene expression in astrocytes. |
|
|
|
|
|
| 95694 | Pilocarpine | Small molecule | Small molecule | Increases expression | indirect | BDNF | Protein | Homo sapiens-e | |
| Pilocarpine caused a transient increase in
hippocampal brain-derived neurotrophic factor (BDNF) levels,
with carbachol and nicotine showing the same trend. | |
| |
Interaction id | 95694 | |
MOLECULE A | |
Id | 92-13-7 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Transmembrane Receptor Protein Tyrosine Kinase
Signaling Pathway:Brain-Derived Neurotrophic Factor
Receptor Signaling Pathway | |
Experimental location and method | - organ / tissue::Hippocampus
| |
References | |
PubMed Id | 10101239 | |
Author | French SJ, Humby T, Horner CH, Sofroniew MV, Rattray M | |
Title | Hippocampal neurotrophin and trk receptor mRNA levels are
altered by local administration of nicotine, carbachol and pilocarpine. |
|
|
|
|
|
| 95697 | Nicotine | Small molecule | Small molecule | Increases expression | indirect | BDNF | Protein | Homo sapiens-e | |
| Pilocarpine caused a transient increase in
hippocampal brain-derived neurotrophic factor (BDNF) levels,
with carbachol and nicotine showing the same trend. | |
| |
Interaction id | 95697 | |
MOLECULE A | |
Id | 54-11-5 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Transmembrane Receptor Protein Tyrosine Kinase
Signaling Pathway:Brain-Derived Neurotrophic Factor
Receptor Signaling Pathway | |
Experimental location and method | - organ / tissue::Hippocampus
| |
References | |
PubMed Id | 10101239 | |
Author | French SJ, Humby T, Horner CH, Sofroniew MV, Rattray M | |
Title | Hippocampal neurotrophin and trk receptor mRNA levels are
altered by local administration of nicotine, carbachol and pilocarpine. |
|
|
|
|
|
| 129764 | Papaverine | Small molecule | Small molecule | Increases expression | indirect | Bdnf | RNA | Rattus norvegicus | |
| Chronic administration of the
phosphodiesterase (PDE) inhibitors rolipram or papaverine
also increased expression of CREB mRNA in hippocampus,
demonstrating a role for the cAMP cascade. / We have found
that levels of brain-derived neurotrophic factor (BDNF) and
trkB mRNA are also increased by administration of
antidepressants or PDE inhibitors. | |
| |
Interaction id | 129764 | |
MOLECULE A | |
Id | 58-74-2 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 24225 |
Type | RNA |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Response to Stimulus:Response to Drug | |
Experimental location and method | - species::Rat
- condition::Chronic administration
- organ / tissue::Hippocampus
| |
References | |
PubMed Id | 8601816 | |
Author | Nibuya M, Nestler EJ, Duman RS | |
Title | Chronic antidepressant administration increases the
expression of cAMP response element binding protein (CREB) in
rat hippocampus. |
|
|
|
|
|
| 207451 | Salicylic Acid | Small molecule | Small molecule | Increases expression | indirect | BDNF | Protein | Homo sapiens-e | |
| Identification of potential compounds
promoting BDNF production in nigral dopaminergic neurons:
clinical implication in Parkinson's disease. /
Parkinson's disease (PD) is characterized by the
selective loss of dopamine (DA) neurons in the substantia
nigral brain region. / Our results demonstrate that
salicyclic acid, cGMP analog, okadaic acid, IBMX,
dipyridamole and glutamate significantly enhance BDNF
production in DA neuronal cells. | |
| |
Interaction id | 207451 | |
MOLECULE A | |
Id | 69-72-7 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | disease: :Parkinson Diseasesignificance: :Therapeutic potential | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Response to Stimulus:Response to Drug | |
Disease Details | | disease: :Parkinson Disease |
| |
Experimental location and method | - cell::Dopaminergic neurons
- organ / tissue::Substantia Nigra
| |
References | |
PubMed Id | 10718305 | |
Author | Chun HS, Son JJ, Son JH | |
Title | Identification of potential compounds promoting BDNF
production in nigral dopaminergic neurons: clinical implication
in Parkinson's disease. |
|
|
|
|
|
| 207456 | Dipyridamole | Small molecule | Small molecule | Increases expression | indirect | BDNF | Protein | Homo sapiens-e | |
| Identification of potential compounds
promoting BDNF production in nigral dopaminergic neurons:
clinical implication in Parkinson's disease. /
Parkinson's disease (PD) is characterized by the
selective loss of dopamine (DA) neurons in the substantia
nigral brain region. / Our results demonstrate that
salicyclic acid, cGMP analog, okadaic acid, IBMX,
dipyridamole and glutamate significantly enhance BDNF
production in DA neuronal cells. | |
| |
Interaction id | 207456 | |
MOLECULE A | |
Id | 58-32-2 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 627 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | disease: :Parkinson Diseasesignificance: :Therapeutic potential | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Response to Stimulus:Response to Drug | |
Disease Details | | disease: :Parkinson Disease |
| |
Experimental location and method | - cell::Dopaminergic neurons
- organ / tissue::Substantia nigra
| |
References | |
PubMed Id | 10718305 | |
Author | Chun HS, Son JJ, Son JH | |
Title | Identification of potential compounds promoting BDNF
production in nigral dopaminergic neurons: clinical implication
in Parkinson's disease. |
|
|
|
|
d: for diseases
Disease