| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 202472 | Valsartan | Small molecule | Small molecule | Decreases expression | indirect | Tnf | Protein | Mus musculus | | | Roles of angiotensin II type 2 receptor
stimulation associated with selective angiotensin II type 1
receptor blockade with valsartan in the improvement of
inflammation-induced vascular injury. / Valsartan attenuated
the expression of MCP-1, TNF-alpha, IL-6, IL-1beta, and
infiltration of leukocytes and macrophages in the injured
arteries; however, these effects of valsartan were less
prominent in Agtr2- mice. / These results suggest that the
stimulation of the AT(2) receptor after AT(1) blockade is
important in the improvement of the inflammatory vascular injury. | | | |
Interaction id | 202472 | |
MOLECULE A | |
Id | 137862-53-4 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 21926 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | | | Kinetics | - | |
|
General Information |
Interaction term | Decreases expression (
indirect ) | |
Pathway | Peptide receptor activity, G-protein
coupled:Angiotensin receptor activity | |
Disease Details | | disease: :Vascular injury |
| |
Experimental location and method | - species::Mouse
- condition::In presence of Agtr2
| |
References | |
PubMed Id | 11723025 | |
Author | Wu L, Iwai M, Nakagami H, Li Z, Chen R, Suzuki J, Akishita
M, de Gasparo M, Horiuchi M | |
Title | Roles of angiotensin II type 2 receptor stimulation
associated with selective angiotensin II type 1 receptor
blockade with valsartan in the improvement of
inflammation-induced vascular injury. |
|
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| |
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