| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 195021 | Beta-Lapachone | Small molecule | Small molecule | Inhibits expression | indirect | Tnf | Protein | Rattus norvegicus | | | beta-Lapachone, a 1,2-naphthoquinone, is a
novel chemotherapeutic agent. / The authors further
performed experiments to examine the molecular mechanism of
beta-lapachone on LPS-induced responses in rat alveolar
macrophages and to evaluate its in vivo antiinflammatory
effect. / beta-Lapachone could also inhibit the production
of tumor necrosis factor-alpha induced by LPS.
/beta-Lapachone, a 1,2-naphthoquinone, is a novel
chemotherapeutic agent. | | | |
Interaction id | 195021 | |
MOLECULE A | |
Id | 4707-32-8 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 24835 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits expression (
indirect ) | |
Disease Details | | disease: :Pulmonary Edema |
| |
Experimental location and method | - species::Rat
- condition::Lipopolysaccharide treated cells
- cell::Alveolar macrophages
| |
References | |
PubMed Id | 12724123 | |
Author | Tzeng HP, Ho FM, Chao KF, Kuo ML, Lin-Shiau SY, Liu SH | |
Title | beta-Lapachone reduces endotoxin-induced macrophage
activation and lung edema and mortality. |
|
|
| |
|
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Disease