| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 14835 | IL1R1 | Protein | Homo sapiens | Bind | direct | RAC1 | Protein | Homo sapiens | | | Glutathione S-transferase (GST) fusion
proteins, containing either the full-length IL-1R cytosolic
domain (GST-IL-1Rcd) or the terminal 68 amino acids of IL-1R
required for IL-1-dependent signal transduction,
specifically coprecipitated both RhoA and Rac-1, but not
p21(ras), from Triton-soluble HeLa cell extracts. | | | |
Interaction id | 14835 | |
MOLECULE A | |
Id | 3554 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5879 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Bind (
direct ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
Disease Details | | |
Experimental location and method | - Experimental method::Immunoprecipitation
- species::Human
- cell::HeLa cells
| |
Comments | |
Domain_motif_site_residue | | (PF01582)[RES:Terminal 68 amino acids](IL1R1) |
| |
References | |
PubMed Id | 10359565 | |
Author | Singh R, Wang B, Shirvaikar A, Khan S, Kamat S, Schelling
JR, Konieczkowski M, Sedor JR | |
Title | The IL-1 receptor and Rho directly associate to drive cell
activation in inflammation. |
|
|
| | |
| 66181 | IL1B | Protein | Homo sapiens-e | Increases expression | indirect | Il1r1 | RNA | Mus musculus | | | Using RT-PCR, we first showed that the
expression of IL-1RI and IL-1RII, but not IL-1RacP, mRNAs
are up-regulated by IL-1 beta in a time-dependent manner. | | | |
Interaction id | 66181 | |
MOLECULE A | |
Id | 3553 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 16177 |
Type | RNA |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
Experimental location and method | - Experimental method::Polymerase Chain Reaction
- species::Mouse
- cell::Primary astrocytes
| |
References | |
PubMed Id | 11723165 | |
Author | Pousset F, Cremona S, Dantzer R, Kelley KW, Parnet P | |
Title | IL-10 and IL-4 regulate type-I and type-II IL-1 receptors
expression on IL-1 beta-activated mouse primary astrocytes. |
|
|
| | |
| 202568 | IL1B | Protein | Homo sapiens-e | Bind | direct | Il1r1 | Protein | Rattus norvegicus | | | In the present study, the role of IL-1
receptor binding sites in the regulation of NGF release was
evaluated by determining the pharmacological properties of
astroglially localized IL-1 receptors, and, by comparing the
effects of both the agonists (IL-1 alpha and IL-1 beta) and
the antagonist (IL-1ra)-members of the IL-1 family on NGF
secretion from rat neonatal cortical astrocytes in primary
culture. / IL-1 receptor agonists IL-1 alpha (K(i) of 341.1
pM) and IL-1 beta (K(i) 59.9 pM), as well as the antagonist
IL-1ra (K(i) 257.6 pM), displaced specific [(125)I] IL-1
beta binding from cultured astrocytes in a monophasic
manner. / We concluded that IL-1 beta-induced NGF secretion
from cultured rat cortical astrocytes is mediated by
functional type I IL-1 receptors, whereas IL-1 alpha and
IL-1ra, in spite of their affinity for IL-1RI, have no
effect on NGF secretion from these cells. | | | |
Interaction id | 202568 | |
MOLECULE A | |
Id | 3553 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 25663 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics |
| |
|
General Information |
Interaction term | Bind (
direct ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
Experimental location and method | - species::Rat
- condition::Neonatal rat
- cell::Cortical astrocytes
| |
References | |
PubMed Id | 11705672 | |
Author | Juric DM, Carman-Krzan M | |
Title | Interleukin-1 beta, but not IL-1 alpha, mediates nerve growth
factor secretion from rat astrocytes via type I IL-1 receptor. |
|
|
| | |
| 202569 | IL1A | Protein | Homo sapiens-e | Bind | direct | Il1r1 | Protein | Rattus norvegicus | | | In the present study, the role of IL-1
receptor binding sites in the regulation of NGF release was
evaluated by determining the pharmacological properties of
astroglially localized IL-1 receptors, and, by comparing the
effects of both the agonists (IL-1 alpha and IL-1 beta) and
the antagonist (IL-1ra)-members of the IL-1 family on NGF
secretion from rat neonatal cortical astrocytes in primary
culture. / IL-1 receptor agonists IL-1 alpha (K(i) of 341.1
pM) and IL-1 beta (K(i) 59.9 pM), as well as the antagonist
IL-1ra (K(i) 257.6 pM), displaced specific [(125)I] IL-1
beta binding from cultured astrocytes in a monophasic
manner. / We concluded that IL-1 beta-induced NGF secretion
from cultured rat cortical astrocytes is mediated by
functional type I IL-1 receptors, whereas IL-1 alpha and
IL-1ra, in spite of their affinity for IL-1RI, have no
effect on NGF secretion from these cells. | | | |
Interaction id | 202569 | |
MOLECULE A | |
Id | 3552 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 25663 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics |
| |
|
General Information |
Interaction term | Bind (
direct ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
Experimental location and method | - species::Rat
- condition::Neonatal rat
- cell::Cortical astrocytes
| |
References | |
PubMed Id | 11705672 | |
Author | Juric DM, Carman-Krzan M | |
Title | Interleukin-1 beta, but not IL-1 alpha, mediates nerve growth
factor secretion from rat astrocytes via type I IL-1 receptor. |
|
|
| |
|
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