| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 79168 | TNF | Protein | Homo sapiens-e | Increases activity | indirect | Protein kinase, cAMP-dependent,
catalytic subunit | Subunit group | Homo sapiens | | | Consistent with the hypothesis that TNF-alpha
induces perilipin hyperphosphorylation by activating PKA,
TNF-alpha increased intracellular cAMP approximately
1.7-fold, and the increase was abrogated by PD98059. | | | |
Interaction id | 79168 | |
MOLECULE A | |
Id | 7124 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | EZHsS00003 |
Type | Subunit group |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:TNF Signaling Pathway | |
References | |
PubMed Id | 12351429 | |
Author | Zhang HH, Halbleib M, Ahmad F, Manganiello VC, Greenberg AS | |
Title | Tumor necrosis factor-alpha stimulates lipolysis in
differentiated human adipocytes through activation of
extracellular signal-related kinase and elevation of
intracellular cAMP. |
|
|
| | |
| 193130 | Protein kinase, cAMP-dependent,
catalytic subunit | Subunit group | Homo sapiens-e | Increases activity | indirect | TTF1 | Protein | Homo sapiens-e | | | We asked whether PKA directly activates TTF1.
We show that cAMP/PKA activates pTg and a synthetic target
promoter carrying TTF1 binding site repeats in several cell
types. Activation depends on TTF1.Phosphopeptide mapping
indicates that TTF1 is constitutively phosphorylated at
multiple sites, and that cAMP stimulated phosphorylation of
one site, serine 337, in vivo. However, alanine substitution
at this residue or at all sites of phosphorylation did not
reduce PKA activation of pTg. Thus, PKA stimulates TTF1
transcriptional activity in an indirect manner, perhaps by
recruiting to or removing from the target promoter another
regulatory factor(s). | | | |
Interaction id | 193130 | |
MOLECULE A | |
Id | EZHsS00003 |
Type | Subunit group |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 7270 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Second-Messenger-Mediated Signaling:cAMP-Mediated SignalingProtein serine/threonine kinase activity:Cyclic
nucleotide-dependent protein kinase activity | |
Experimental location and method | - Experimental method::Mutation analysis
| |
Comments | |
Property | | Mutated molecule:TTF1(Ser337Ala) |
| |
References | |
PubMed Id | 11149600 | |
Author | Feliciello A, Allevato G, Musti AM, De Brasi D, Gallo A,
Avvedimento VE, Gottesman ME | |
Title | Thyroid transcription factor 1 phosphorylation is not
required for protein kinase A-dependent transcription of the
thyroglobulin promoter. |
|
|
| |
|
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