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We examined the effect of peroxisome
proliferator-activated receptor (PPAR) activators on
inflammatory responses in cultured rat brain glial cells.
Four PPAR-alpha activators were tested, three fibrates
(WY14643, clofibrate and fenofibrate) and an arachidonic
acid derivative (5,8,11,14-eicosatetraynoic acid). /
PPAR-alpha activators also suppressed
lipopolysaccharide-stimulated tumor necrosis factor-alpha
and monocyte chemoattractant protein-1 transcription and release.