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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
192504ClofibrateSmall moleculeSmall moleculeDecreases releaseindirectTnfProteinRattus norvegicus
We examined the effect of peroxisome proliferator-activated receptor (PPAR) activators on inflammatory responses in cultured rat brain glial cells. Four PPAR-alpha activators were tested, three fibrates (WY14643, clofibrate and fenofibrate) and an arachidonic acid derivative (5,8,11,14-eicosatetraynoic acid). / PPAR-alpha activators also suppressed lipopolysaccharide-stimulated tumor necrosis factor-alpha and monocyte chemoattractant protein-1 transcription and release.